Conversion of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its 5-Methyl Analog into Pyridinium Salts
Monoamine oxidase B metabolizes 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 1) first to 1-methyl-4-phenyl-2,3-dihydropyridinium salt (MPDP+; 5), and then to 1-methyl-4-phenylpyridinium salt (MPP+; 7).Chemical synthesis of MPD
Gessner, Wieslaw,Brossi, Arnold,Shen, Rong-sen,Fritz, Richard R.,Abell, Creed W.
REDUCTION OF PHENYL-SUBSTITUTED PYRIDINIUM METHOIODIDES WITH SODIUM BOROHYDRIDE. FORMATION OF AMINE-BORANE COMPLEXES IN WATER.
Reduction of phenyl-substituted pyridinium methoiodides with sodium borohydride in water afforded besides the desired tetrahydropyridines substantial amounts of amine-borane complexes.Reduction in methanol afforded tetrahydropyridines in high yield, with almost no amine-boranes formed.
Gessner, Wieslaw,Brossi, Arnold
p. 911 - 916
(2007/10/02)
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