- Isolation, identification, semi-synthesis of aziditaxel derivatives and their biological evaluation
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Two new taxoids (5 and 6) were obtained by isolating impurities in aziditaxel, and their structures were characterized based on data analysis of 1H NMR, 13C NMR, HPLC-MS, and through comparison with literature. In order to test their cytotoxicities against human nonsmall lung cancer cell lines (A549), sufficient amounts of compounds 5 and 6 were obtained by semi-synthesis and both of them showed equipotent cytotoxiesty compared with taxol, docetaxel, and aziditaxel.
- Zhang, Shu-En,Tao, Jia-Yi,Zhao, Ying,Wang, Shao-Rong,Zhou, Di,Fang, Wei-Shuo
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p. 463 - 475
(2012/07/14)
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- Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport
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Some C-7 modified analogs of 3, a taxane with high affinity for binding to microtubules, were prepared through multistep transformations. Most of the analogs, bearing less lipophilic C-7 substituents than propionyl in 3, exhibited comparable binding affin
- Xiao, Xi,Wu, Ju,Trigili, Chiara,Chen, Hui,Chu, Joseph W.K.,Zhao, Ying,Lu, Peihua,Sheng, Li,Li, Yan,Sharom, Frances J.,Barasoain, Isabel,Diaz, J. Fernando,Fang, Wei-Shuo
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p. 4852 - 4856
(2011/09/21)
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