- Nucleophilic addition of dilithiated amides to 3-substituted pyridines
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Dilithiated amides (2), derived from N-phenyl or N-methylacetamide and n-BuLi, react with 3-cyanopyridine (1a), 3-(1,3-oxazol-2-in-2-yl)pyridine) (1b) or 3-(4,4-dimethyl 1,3-oxazol-2-in-2-yl)pyridine (1c) to give dihydropyridines.The major isomer obtained in each case is the 1,6-dihydropyridine (3a-f)
- Whitney, Ralph Allen,Boyle, John M.
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