- Salts And Co-Crystals of Pyrazolopyrimidine Compounds, Compositions Thereof And Methods For Their Production And Use
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The invention provides pharmaceutically acceptable salts and co-crystals of pyrazolopyrimidine compounds such as zaleplon, indiplon and ocinaplon, processes for their preparation, compositions comprising such salts and co-crystals and methods of using such salts and co-crystals for treating various diseases and conditions.
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Page/Page column 10
(2010/11/30)
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- NOVEL HETEROBICYCLIC COMPOUNDS
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This invention relates to novel pyrazolo-pyrimidine compounds and their use as analytical tools and in methods of treating neurological disorders, including sleep disorders such as insomnia.
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Page/Page column 42
(2010/11/29)
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- Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: Exploration of core and headpiece structure-activity relationships
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A novel series of antiproliferative agents containing pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides, selective for p21-deficient cells, were identified by high-throughput screening. Exploration of the SAR relationships in the headpiece, core, and tailpiece
- Powell, Dennis,Gopalsamy, Ariamala,Wang, Yanong D.,Zhang, Nan,Miranda, Miriam,McGinnis, John P.,Rabindran, Sridhar K.
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p. 1641 - 1645
(2007/10/03)
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- Method of using substituted pyrazolo [1,5-a] pyrimidines
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This invention relates to novel methods of use of certain pyrazolo[1,5-a]pyrimidine compounds and the therapeutically acceptable salts thereof. This invention also relates to novel methods of using these compounds as anti-proliferative agents in mammals, including humans.
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Page/Page column 45
(2010/10/20)
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- Substituted pyrazolo[1,5-a] pyrimidines and process for making same
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This invention relates to novel pyrazolo[1,5-a]pyrimidine compounds and the therapeutically acceptable salts thereof. These compounds are useful as anti-proliferative agents in mammals, including humans.
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Page/Page column 50
(2010/10/20)
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- Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: Parallel synthesis for lead optimization of amide region
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A novel series of p21 chemoselective agents containing a pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides were identified by high throughput screening. Optimization of the amide region by parallel synthesis and the iterative design toward understanding structu
- Gopalsamy, Ariamala,Yang, Hui,Ellingboe, John W.,Tsou, Hwei-Ru,Zhang, Nan,Honores, Erick,Powell, Dennis,Miranda, Miriam,McGinnis, John P.,Rabindran, Sridhar K.
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p. 1591 - 1594
(2007/10/03)
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- N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
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N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide, and use of the same as a sedative-hypnotic, anxiolytic, anticonvulsant, and skeletal muscle relaxant agent. Compositions containing N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide, as well as pharmaceutically acceptable salts thereof, are also disclosed.
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