The mechanism of enzymic hydroxyl group removal from C-21 of tetrahydrodeoxycorticosterone
The C-21 hydroxyl group of C-17- and C-21-deuterium labelled tetrahydrodeoxycorticosterone is removed by the anaerobic intestinal bacterium Eubacterium lentum ATCC 25559 with retention of deuterium label at C-17α and loss of one of the two deuterium atoms originally present at C-21.Dehydroxylation at C-21 proceeds with an apparent primary kinetic isotope effect, KH/KD at C-21 of 2.6.These data suggest a route for C-21 dehydroxylation involving a C-20(21)-enediol intermediate.
Holland, Herbert L.,Riemland, Elly
p. 981 - 983
(2007/10/02)
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