N-heterocyclic carbene-palladium-imine complex catalyzed α-arylation of ketones with aryl and heteroaryl chlorides under air atmosphere
A new structure of saturated ring skeleton monoligated NHC-Pd-Imine complex was easily synthesized and unambiguously confirmed by X-ray single crystal diffraction. It was found to be an efficient and air-stable catalyst for the α-arylation of ketones. The reaction could be operated in air without any negative effect. Non-activated aryl and heteroaryl chlorides have been successfully applied in the reaction with only 0.5 mol% catalyst loadings under air atmosphere. Excellent to good product yields were afforded.
Pyridazines. XXIII . A Novel Pyridazine into Pyrazole Ring Transformation
Treatment of phenyl(4-pyridazinyl)methanols 1a and 1b with p-toluenesulfonic acid at elevated temperatures causes transformation into the C-4 substituted pyrazole derivatives 8a and 8b.Limitations of this novel rearrangement reaction as well as mechanistic considerations are discussed.Furthemore, the preparation of hitherto unknown 4-pyridazinylmethanols 1b, 3, and 7 is described.
Heinisch, Gottfried,Waglechner, Richard
p. 1727 - 1731
(2007/10/02)
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