A highly efficient strategy for modification of proteins at the C terminus
A new linker: In a facile, chemoselective, and potentially general method for protein modification at the C terminus oxyamino-modified proteins obtained from protein thioesters react rapidly with ketones under mild conditions. This strategy was used for fluorescence labeling, for example with modified coumarin and fluorescein (see scheme). Copyright
Yi, Long,Sun, Hongyan,Wu, Yao-Wen,Triola, Gemma,Waldmann, Herbert,Goody, Roger S.
supporting information; experimental part
p. 9417 - 9421
(2011/02/23)
New serotonin 5-HT1F agonists
This invention provides novel 5-HT1Fagonists of formula where X, Y, Z,and R are defined in the specification, which are useful for the prevention and treatment of migraine and associated disorders.
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(2008/06/13)
Anti-tumor platinum complexes
Platinum complexes, having anti-tumor activity, which include at least one functional ketone group or aldehyde, optionally conjugated as a linkable hydrazone complex. The functional ketone and aldehyde groups and the functionalized hydrazone complexes are
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(2008/06/13)
Molecular analytical release tags and their use in chemical analysis
A release tag reagent suitable for use in the chemical analysis of a substance to be detected, which substance contains reactive groups, such as for, but not limited to gas phase detection groups, which reagent comprises three covalently bonded groups: a
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(2008/06/13)
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