- PROSTAGLANDIN E2 (PGE2) EP4 RECEPTOR ANTAGONISTS
-
The present invention relates to novel compounds of formula (I) and pharmaceutical compositions containing these compounds. The compounds provided herein can act as prostaglandin E2 (PGE2) EP4 receptor antagonists, which renders them highly advantageous for use in therapy, particularly in the treatment or prevention of cancer, a neovascular eye disease, inflammatory pain, or an inflammatory disease, such as, e.g., multiple sclerosis, rheumatoid arthritis or endometriosis.
- -
-
Page/Page column 78; 80; 175
(2021/04/10)
-
- DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS
-
Compounds of formula I: I are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disorders in a patient in need are also disclosed. Such disorders include depression, bipolar disorder, pain, schizophrenia, obsessive compulsive disorder, addiction, social disorder, attention deficit hyperactivity disorder, an anxiety disorder, autism, a cognitive impairment, or a neuropsychiatric symptom such as apathy, depression, anxiety, psychosis, aggression, agitation, impulse control disorders, and sleep disorders in neurological disorders such as Alzheimer's and Parkinson's diseases.
- -
-
Paragraph 0307
(2018/03/28)
-
- BICYCLIC NITROGEN COMPOUNDS AS MODULATORS OF GHRELIN RECEPTOR AND USES THEREOF
-
Disclosed herein are compounds of Formula I as defined herein, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, that modulates the activity of a ghrelin receptor. Disclosed herein are also methods of treating diseases or conditions that comprise administering to a subject in need thereof a therapeutically effective amount of a compound of Formula I.
- -
-
Page/Page column 102
(2010/11/28)
-
- Analgesic substituted-1-aminoalkylamino-4-aryloxypiperidines
-
There are described analgesic substituted-1-aminoalkylamino-4-aryloxypiperidines of the formula STR1 where X is hydrogen, loweralkyl, CF3, acetyl or halogen; n is 1 or 2; R1 is H2 or oxygen; R2 is H, loweralkyl
- -
-
-
- Piperidylalkylindoles. 1. Hypotensive activity of 3-[2-(phenoxypiperidyl)ethyl]indoles
-
A series of 3-[2-(phenoxypiperidyl)ethyl]indoles was synthesized and evaluated for hypotensive activity in the spontaneous hypertensive rat. Maximum hypotensive activity appeared when the phenoxy substituent was para substituted and occupied the 4 position of the piperidine ring.
- Helsley,Strupczewski,Woodward
-
p. 309 - 312
(2007/10/05)
-