- MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF
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The disclosure relates to compounds and pharmaceutical compositions capable of modulating the hydroxysteroid 17-beta dehydrogenase (HSD17B) family member proteins including inhibiting the HSD17B member proteins, e.g. HSD17B13. The disclosure further relates to methods of treating liver diseases, disorders, or conditions with the compounds and pharmaceutical compositions disclosed herein, in which the HSD17B family member protein plays a role.
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Paragraph 0331
(2021/01/23)
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- Synthesis of non-nucleoside anti-viral cyclopropylcarboxacyl hydrazones and initial anti-HSV-1 structure-activity relationship studies
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The synthesis of a lead anti-viral cyclopropyl carboxy acyl hydrazone 4F17 (5) and three sequential arrays of structural analogues along with the initial assessment and optimization of the antiviral pharmacophore against the herpes simplex virus type 1 (HSV-1) are reported.
- Babu Dokuburra, Chanti,D'Aiuto, Leonardo,Demers, Matthew,McClain, Lora,McNulty, James,Nimgaonkar, Vishwajit L.,Piazza, Paolo,Williamson, Kelly,Zheng, Wenxiao
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- Ligand-Free Palladium-Catalyzed Oxidative Carbonylative Homocoupling of Arylboron Reagents at Ambient Pressure
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Arylboronic acids or potassium aryltrifluoroborates were readily oxidatively carbonylated to their corresponding diaryl ketones in high yields with high selectivities by ligand-free palladium-catalyzed homocoupling at atmospheric pressure. This novel method employs molecular oxygen or iodine as the oxidant and offers an attractive alternative to transition-metal-based oxidant systems.
- Zhao, Hongyuan,Han, Wei
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supporting information
p. 4279 - 4283
(2016/09/14)
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- SMALL MOLECULE LFA-1 INHIBITORS
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The present invention relates to novel compounds which are capable of inhibiting the interaction of LFA-1 with its counter ligands.
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- Palladium-catalyzed oxidative carbonylation for the synthesis of symmetrical diaryl ketones at atmospheric co pressure
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A mild and efficient synthesis of symmetrical diaryl ketones by palladium-catalyzed oxidative carbonylation of arylboronic acids with carbon monoxide at atmospheric pressure is reported. Georg Thieme Verlag Stuttgart New York.
- Li, Yang,Lu, Wei,Xue, Dong,Wang, Chao,Liu, Zhao-Tie,Xiao, Jianliang
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supporting information
p. 1097 - 1100
(2014/05/20)
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- NOVEL BENZODIOXOLES
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The present invention relates to compound of formula (I) Wherein R1, R2, R3, R4, R5, R6, R7, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases, which are associated with the modulation of CB1 receptors.
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- Acylation du trifluoromethoxybenzene en catalyse HF-BF3
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Friedel and Crafts acylation of trifluoromethoxy- and trifluoromethyl-thiobenzene fails to give ketones in a one step synthesis if chlorinated Lewis acids (AlCl3) are used, because of halogen exchange on the -OCF3 and -SCF3 groups.The use of a fluorinated catalyst system such as HF-BF3 avoids exchange reactions and acylation occurs smoothly under mild conditions: - Low temperature and pressure - High yields (very often >90 percent) - Very high para-regioselectivity.Related reactions such as formylation or sulfonylation can also be achieved under similar conditions.
- Desbois, Michel
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p. 885 - 890
(2007/10/02)
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