Preparative syntheses of optically pure ortho-substituted benzhydrols by asymmetric reductions of the corresponding benzophenones
Lithium aluminium hydride previously treated with 2.5 equivalents of (S)-(+) or (R)-(-)-2-(2-iso-indolinyl)butan-1-ol 3 (readily available reagents) reduced the five ortho-substituted benzophenones 4-6, 8 and 10 into the corresponding optically active benzhydrols with nearly 100% enantiomeric excesses. Other examples of asymmetric reductions of prochiral benzophenones are given.
Brown,Leze,Touet
p. 841 - 844
(2007/10/02)
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