- Preparation method of cartap intermediate
-
The invention relates to a preparation method of cartap intermediate and belongs to the technical field of heterocyclic compounds. The preparation method comprises the following steps: in an organic solvent, enabling 1,2,3-trihalogenated propane to react with thiocyanate at a certain temperature to obtain 1,3-dithiocyano-2-halogenated propane; in a polar organic solvent, under the existence of alkali, performing nucleophilic substitution reaction on the 1,3-dithiocyano-2-halogenated propane and dimethylamine; after the reaction is ended, extracting, drying, concentrating and purifying reaction liquid to obtain 2-dimethylamino-1,3-dithiocyanopropane. The preparation method provided by the invention is applied to the synthesis of the cartap intermediate, so that the generation of an isomer is avoided, the reaction synthesis rate is improved, and the use of sodium cyanide is also avoided; the preparation method has the advantages of being good in reaction greenness, simple to operate, high in synthesis rate and the like.
- -
-
Paragraph 0059; 0060; 0061; 0062; 0063; 0064; 0065-0067
(2017/07/20)
-
- Synthetic process of cartap intermediate
-
The invention relates to a synthetic process of a cartap intermediate, and belongs to the technical field of heterocyclic compounds. The synthetic process comprises the following steps: in an organic solvent, enabling 1,3-dichloroacetone to react with thiocyanate at a certain temperature to obtain 1,3-dithiocyano-2-halogenated propane; in a high-pressure reaction vessel, under the existence of a catalyst and a reaction solvent, performing catalytic hydrogenation reaction on a crude product obtained in the step (1) and a dimethylamine aqueous solution under a certain hydrogen pressure; after the reaction is ended, filtering, extracting, concentrating and purifying to obtain 2-dimethylamino-1,3-dithiocyanopropane. The synthetic process provided by the invention is applied to the synthesis of the cartap intermediate, so that the generation of an isomer is avoided, the reaction synthesis rate is improved, and the use of sodium cyanide is also avoided; the synthetic process has the advantages of being good in reaction greenness, simple to operate, high in synthesis rate and the like.
- -
-
Paragraph 0044; 0045; 0046; 0047; 0048; 0049-0052
(2017/07/19)
-