- Synthesis and antibacterial evaluation of novel 8-fluoro Norfloxacin derivatives as potential probes for methicillin and vancomycin-resistant Staphylococcus aureus
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A series of novel 8-fluoro Norfloxacin derivatives and the hybrids of its piperazinyl derivatives incorporated with 1,3,5-triazine and pyrimidine were synthesized. All the above compounds were evaluated for their antibacterial activity against Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus and methicillin & vancomycin-resistant S. aureus. Among all, compounds having Morpholine, N-methyl/phenyl/benzyl/pyrimidinyl piperazines and n-butylamine substitution at C-7 position, have shown increased potency in comparison to norfloxacin and ciprofloxacin.
- Sunduru, Naresh,Gupta, Leena,Chauhan, Kuldeep,Mishra, Nripendra N.,Shukla, Praveen K.,Chauhan, Prem M.S.
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experimental part
p. 1232 - 1244
(2011/04/22)
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- NOVEL METHOD OF SYNTHESIS OF FLUOROQUINOLONES
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The invention relates to a method of preparation of fluoroquinolones of formula (I) from compounds of formula (II): in which R1, R2, R3, R4, R5, R6, R7, and X are as defined in Claim 1.
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Page/Page column 6-8
(2009/04/24)
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- Microwave assisted amination of quinolone carboxylic acids: An expeditious synthesis of fluoroquinolone antibacterials
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A facile amination of quinolone carboxylic acids to fluoroquinolone antibacterials under microwave irradiation is described.
- Reddy,Baskaran
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p. 6775 - 6777
(2007/10/03)
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- Process for the preparation of quinoline carboxylic acid derivatives
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The invention relates to a new process for the preparation of antibacterial compounds of the Formula I STR1 wherein R1 stands for phenyl substituted by 1 or 2 halogen atoms; R2 stands for piperazinyl or 4-methyl-piperazinyl; and pharmaceutically acceptable salts thereof which comprises using a compound of the Formula II STR2 wherein R stands for halogen or an aliphatic acyloxy group containing 2 to 6 carbon atoms or an aromatic acyloxy group containing 7 to 11 carbon atoms and R4 stands for fluorine or chlorine as a starting material.
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