Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): STR1 and pharmaceutically acceptable salts of the
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(2008/06/13)
3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors. 3. 7-(3,5-Disubstituted -2-yl)-3,5-dihydroxy-6-heptenoic Acids and Their Lactone Derivatives
The syntheses of a series of 7-(3,5-disubstituted -2-yl)-3,5-dihydroxy-6-heptenoic acids and their lactones are reported.Intrinsic 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitory activity is enhanced markedly when the biphenyl mo
Stokker, G. E.,Alberts, A. W.,Anderson, P. S.,Cragoe, E. J.,Deana, A. A.,et al.
p. 170 - 181
(2007/10/02)
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