- 5-Substituted 4-isoxazolecarboxamides with platelet antiaggregating and other activities
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The synthesis of a series of 5-substituted 4-isoxazolecarboxamides by reaction of eight 5-substituted 4-isoxazolecarbonyl chlorides with pyrrolidine, piperidine, morpholine and 4-trifluoromethylaniline is described. Some of these amides showed platelet antiaggregating activity in vitro slightly inferior to that of acetylsalicylic acid, as well weak antiinflammatory, analgesic and antipyretic activities in rats and mice.
- Fossa,Menozzi,Schenone,Filipelli,Russo,Lucarelli,Marmo
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p. 789 - 802
(2007/10/02)
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- Isoxazole derivatives and medicaments containing these compounds
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4-Isoxazolecarboxylic acid amides of the general formula I STR1 in which R denotes hydrogen, alkyl with up to 4 carbon atoms or halogenoalkyl with up to 2 carbon atoms and W denotes a direct bond, CH2, CH--CH3, CH--C2 H5, CHOH, O or S, processes for their preparation, medicaments which contain these compounds and the use of the compounds for the treatment of pain and/or fever.
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