- 1,1,2,2-Tetrahydroperoxy-1,2-Diphenylethane: An efficient and high oxygen content oxidant in various oxidative reactions
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Several oxidative approaches namely thiocyanation of aromatic compounds, epoxidation of alkenes, amidation of aromatic aldehydes, epoxidation of α β-unsaturated ketones, oxidation of sulfides to sulfoxides and sulfones, bayer-villeger reaction, bromination and iodation of aniline and phenol derivatives oxidative esterification, oxidation of pyridines and oxidation of secondary, allylic and benzyllic alcohols were carried out using 1,1,2,2-Tetrahydroperoxy-1,2-Diphenylethane as the potential solid oxidant which can be stored for several months without any loss in its activity. All of the procedures were accomplished via mild reaction conditions and the products were afforded in high yields and short reaction times.
- Khosravi, Kaveh,Naserifar, Shirin
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supporting information
p. 6584 - 6592
(2018/10/05)
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- Novel Br?nsted acidic ionic liquids catalyzed one-pot reaction of highly green regioselective thiocyanation of N-containing aromatic and heteroaromatic compounds at room temperature
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In this method, a novel Br?nsted acidic ionic liquid silica-supported pyridinium sulfonic acid thiocyanate {SiO2@[Pyridine-SO3H]SCN} and sulfonic acid-functionalized pyridinium chloride {[PSA]Cl} were easily synthesized and character
- Sajjadifar, Sami,Mansouri, Ghobad,Nikseresht, Ahmad,Kakaei Azani, Fatemeh
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p. 294 - 307
(2018/02/06)
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- 1-methyl-3-(2-(Sulfooxy)Ethyl)-1H-imidazol-3-ium thiocyanate as a novel, green, and efficient bronsted acidic ionic liquid-promoted regioselective thiocyanation of aromatic and heteroaromatic compounds at room temperature
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An efficient and simple method for the preparation of 1-methyl-3-(2- (sulfooxy)ethyl)-1H-imidazol-3-ium thiocyanate ([Msei]SCN) as a Bronsted acidic ionic liquid (BAIL) is described, and it is used in the highly efficient regioselective thiocyanation of aromatic and heteroaromatic compounds via a green and simple protocol. [Msei]SCN as a novel IL and thiocyanation agent, H2O2 as a mild and environmentally friendly oxidant, and H2O:ethanol(1:4) as a solvent were used. This procedure provided the target thiocyanates in high yield and very short reaction time. [Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements for the following free supplemental files: Additional figures.]
- Sajjadifar, Sami,Hosseinzadeh, Hossein,Ahmadaghaee, Saied,Rezaee Nezhad, Eshagh,Karimian, Saaid
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p. 333 - 342
(2014/03/21)
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- Simple and highly efficient catalytic thiocyanation of aromatic compounds in aqueous media
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Two simple, mild, and efficient procedures for the thiocyanation of N-heterocycles, substituted anilines (electron-rich and electron-deficient), and N-substituted aromatic amines at room temperature are reported (Table3). The first uses H2Osub
- Khazaei, Ardeshir,Zolfigol, Mohammad Ali,Mokhlesi, Mohmmad,Panah, Fateme Derakhshan,Sajjadifar, Sami
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experimental part
p. 106 - 114
(2012/02/14)
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- Silica-bonded vanadic acid [SiO2-VO(OH)2] as a heterogeneous and recyclable catalyst for thiocyanation of organic compounds in aqueous media at room temperature
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Silica vanadic acid (in which vanadium oxytrichloride has been supported on silica) is applied as an efficient, reusable and heterogeneous catalyst for the thiocyanation of heterocycles, substituted anilines (electron-rich and electron-deficient) and N-su
- Khazaei, Ardeshir,Zolfigol, Mohammad Ali,Safaiee, Maliheh,Mokhlesi, Mohammad,Donyadari, Elmira,Shiri, Morteza,Kruger, Hendrik Gerhardus
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experimental part
p. 34 - 38
(2012/08/28)
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- Heterogeneous and catalytic thiocyanation of aromatic compounds in aqueous media
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This article describes a highly efficient heterogeneous catalytic thiocyanation of indoles, substituted anilines (electron rich and electron deficient) and N-substituted aromatic amines in water under mild and green conditions. The reaction of substrates
- Zolfigol, Mohammad Ali,Khazaei, Ardeshir,Mokhlesi, Mohammad,Vahedi, Hoshang,Sajadifar, Sami,Pirveysian, Mahtab
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experimental part
p. 295 - 304
(2012/04/04)
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- Citric acid as a trifunctional organocatalyst for thiocyanation of aromatic and heteroaromatic compounds in aqueous media
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A green and simple procedure for the thiocynation of aromatic and heteroaromatic rings in the presence of a catalytic amount of citric acid in water are described. The reactions proceed in high yields, with short reaction times and under mild conditions.
- Khazaei, Ardeshir,Zolfigol, Mohammad Ali,Mokhlesi, Mohmmad,Pirveysian, Mahtab
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experimental part
p. 427 - 432
(2012/06/16)
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- Effects of aromatic thiols on thiol-disulfide interchange reactions that occur during protein folding
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The folding of disulfide containing proteins from denatured protein to native protein involves numerous thiol-disulfide interchange reactions. Many of these reactions include a redox buffer, which is a mixture of a thiol (RSH) and the corresponding disulfide (RSSR). The relationship between the structure of RSH and its efficacy in folding proteins in vitro has been investigated only to a limited extent. Reported herein are the effects of aliphatic and especially aromatic thiols on reactions that occur during protein folding. Aromatic thiols may be particularly efficacious as their thiol pKa values and reactivities match those of the in vivo catalyst, protein disulfide isomerase (PDI). This investigation correlates the thiol pKa values of aromatic thiols with their reactivities toward small molecule disulfides and the protein insulin. The thiol pKa values of nine para-substituted aromatic thiols were measured; a Hammett plot constructed using σp- values yielded ρ = -1.6 ± 0.1. The reactivities of aromatic and aliphatic thiols with 2-pyridyldithioethanol (2-PDE), a small molecule disulfide, were determined. A plot of reactivity versus pKa of the aromatic thiols had a slope (β) of 0.9. The ability of these thiols to reduce (unfold) the protein insulin correlates strongly with their ability to reduce 2-PDE. Since the reduction of protein disulfides occurs during protein folding to remove mismatched disulfides, aromatic thiols with high pKa values are expected to increase the rate not only of protein unfolding but protein folding as well.
- DeCollo,Lees
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p. 4244 - 4249
(2007/10/03)
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