10517-44-9 Usage
Description
1,3-Diaminopropane Dihydrochloride is a chlorinated form of 1,3-Diaminopropane (D416660), a common chemical reagent with a low water content. It is characterized by its two amine groups and a propane backbone, which contribute to its reactivity and versatility in various chemical reactions.
Uses
Used in Pharmaceutical Industry:
1,3-Diaminopropane Dihydrochloride is used as a key intermediate in the synthesis of 7-methoxytacrine-adamantylamine heterodimers. These heterodimers function as cholinesterase inhibitors, which are applied in the treatment of Alzheimer's disease. They help improve cognitive function by increasing the levels of acetylcholine in the brain.
Used in Pharmaceutical Industry:
1,3-Diaminopropane Dihydrochloride is also utilized in the synthesis of thrombosis inhibitors. These inhibitors play a crucial role in preventing blood clot formation, which can lead to life-threatening conditions such as heart attacks, strokes, and deep vein thrombosis. By inhibiting the formation of blood clots, these compounds help maintain proper blood flow and reduce the risk of clot-related complications.
Purification Methods
Crystallise the salt from EtOH/H2O. [Beilstein 4 IV 1258 free base.]
Check Digit Verification of cas no
The CAS Registry Mumber 10517-44-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,5,1 and 7 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 10517-44:
(7*1)+(6*0)+(5*5)+(4*1)+(3*7)+(2*4)+(1*4)=69
69 % 10 = 9
So 10517-44-9 is a valid CAS Registry Number.
InChI:InChI=1/C3H10N2.2ClH/c4-2-1-3-5;;/h1-5H2;2*1H
10517-44-9Relevant articles and documents
Myers,Rose
, p. 1238,1245 (1973)
A Modular Phosphorylated Glycoluril-Derived Molecular Tweezer for Potent Binding of Aliphatic Diamines
Heilmann, Michael,Tiefenbacher, Konrad
, p. 12900 - 12904 (2019)
A molecular tweezer based on a glycoluril-derived framework bearing four phosphate groups was synthesized and shown to be capable of binding organic amines in aqueous solution. This work reports the Ka values for 30 complexes of this molecular tweezer and amine guests, determined by means of 1H NMR titrations. Both the hydrophobic cavity and the phosphate groups contribute to the binding. Bulkier molecules and molecules bearing negatively charged groups like carboxylates in amino acids bind less tightly due to a steric clash and coulombic repulsion. The narrow cavity and the strong ionic interactions of the phosphate groups with ammonium guests favor binding of aliphatic diamines. These binding properties clearly distinguish this system from structurally related molecular clips and tweezers.
AN IMPROVED GENERAL PROCEDURE FOR THE SYNTHESIS OF N,N'-BISACRYLYLDIAMINOALKANES
Helpern, Joseph A.,Sparrow, James T.
, p. 569 - 572 (2007/10/02)
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