132997-77-4Relevant articles and documents
Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide ns3 protease inhibitor for the treatment of hepatitis C virus infection
Scola, Paul M.,Wang, Alan Xiangdong,Good, Andrew C.,Sun, Li-Qiang,Combrink, Keith D.,Campbell, Jeffrey A.,Chen, Jie,Tu, Yong,Sin, Ny,Venables, Brian L.,Sit, Sing-Yuen,Chen, Yan,Cocuzza, Anthony,Bilder, Donna M.,D'Andrea, Stanley,Zheng, Barbara,Hewawasam, Piyasena,Ding, Min,Thuring, Jan,Li, Jianqing,Hernandez, Dennis,Yu, Fei,Falk, Paul,Zhai, Guangzhi,Sheaffer, Amy K.,Chen, Chaoqun,Lee, Min S.,Barry, Diana,Knipe, Jay O.,Li, Wenying,Han, Yong-Hae,Jenkins, Susan,Gesenberg, Christoph,Gao, Qi,Sinz, Michael W.,Santone, Kenneth S.,Zvyaga, Tatyana,Rajamani, Ramkumar,Klei, Herbert E.,Colonno, Richard J.,Grasela, Dennis M.,Hughes, Eric,Chien, Caly,Adams, Stephen,Levesque, Paul C.,Li, Danshi,Zhu, Jialong,Meanwell, Nicholas A.,McPhee, Fiona
, p. 1708 - 1729 (2014/04/03)
The discovery of BMS-605339 (35), a tripeptidic inhibitor of the NS3/4A enzyme, is described. This compound incorporates a cyclopropylacylsulfonamide moiety that was designed to improve the potency of carboxylic acid prototypes through the introduction of favorable nonbonding interactions within the S1′ site of the protease. The identification of 35 was enabled through the optimization and balance of critical properties including potency and pharmacokinetics (PK). This was achieved through modulation of the P2* subsite of the inhibitor which identified the isoquinoline ring system as a key template for improving PK properties with further optimization achieved through functionalization. A methoxy moiety at the C6 position of this isoquinoline ring system proved to be optimal with respect to potency and PK, thus providing the clinical compound 35 which demonstrated antiviral activity in HCV-infected patients.
Compounds for PIM kinase inhibition and for treating malignancy
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, (2011/06/26)
The present invention relates to the compounds of formula I as well as to their use as PIM kinase inhibitors and, thereby, their use for treating oncological diseases, particularly of the hematopoietic system, the liver and the prostate gland
COMPOUNDS FOR PIM KINASE INHIBITION AND FOR TREATING MALIGNANCY
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Page/Page column 20, (2011/06/16)
The present invention relates to the compounds of formula (I) as well as to their use as PIM kinase inhibitors and, thereby, their use for treating oncological diseases, particularly of the hematopoietic system, the liver and the prostate gland.