138775-07-2 Usage
Description
FMOC-ORN(Z)-OH, also known as 9-fluorenylmethoxycarbonyl-L-ornithine benzyl ester, is a synthetic compound commonly utilized in the field of organic chemistry and peptide synthesis. It is a white to off-white powder with specific chemical properties that make it a valuable intermediate in the creation of various peptide derivatives.
Uses
Used in Pharmaceutical Industry:
FMOC-ORN(Z)-OH is used as a synthetic intermediate for the development of cyclic aminohexapeptides and other peptide derivatives. These compounds have potential applications in various therapeutic areas, including antifungal treatments.
Used in Organic Chemistry:
In the field of organic chemistry, FMOC-ORN(Z)-OH serves as a crucial building block for the synthesis of complex molecules and compounds. Its unique structure allows for the creation of a wide range of peptide-based products with diverse applications.
Used in Antifungal Applications:
FMOC-ORN(Z)-OH is used as a key component in the synthesis of antifungal agents, particularly cyclic aminohexapeptides. These agents are effective in combating fungal infections and can be used to develop new drugs for the treatment of various fungal diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 138775-07-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,7,7 and 5 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 138775-07:
(8*1)+(7*3)+(6*8)+(5*7)+(4*7)+(3*5)+(2*0)+(1*7)=162
162 % 10 = 2
So 138775-07-2 is a valid CAS Registry Number.
138775-07-2Relevant articles and documents
Total synthesis and antifungal evaluation of cyclic aminohexapeptides
Klein, Larry L.,Li, Leping,Chen, Hui-Ju,Curty, Cynthia B.,Degoey, David A.,Grampovnik, David J.,Leone, Christina L.,Thomas, Sheela A.,Yeung, Clinton M.,Funk, Kenneth W.,Kishore, Vimal,Lundell, Edwin O.,Wodka, Dariusz,Meulbroek, Jon A.,Alder, Jeffrey D.,Nilius, Angela M.,Lartey, Paul A.,Plattner, Jacob J.
, p. 1677 - 1696 (2007/10/03)
The need for new therapies to treat systemic fungal infections continues to rise. Naturally occurring hexapeptide echinocandin B (1) has shown potent antifungal activity via its inhibition of the synthesis of β-1,3 glucan, a key fungal cell wall component. Although this series of agents has been limited thus far based on their physicochemical characteristics, we have found that the synthesis of analogues bearing an aminoproline residue in the 'northwest' position imparts greatly improved water solubility (>5 mg/mL). The synthesis and structure-activity relationships (SAR) based on whole cell and upon in vivo activity of the series of compounds are reported. Copyright (C) 2000 Elsevier Science Ltd.
