189195-41-3Relevant articles and documents
Optically Active Helical Lanthanide Complexes: Storable Chiral Lewis Acidic Catalysts for Enantioselective Diels–Alder Reaction of Siloxydienes
Harada, Shinji,Nakashima, Saki,Nishida, Atsushi,Oishi, Wakana,Sekino, Shihori
, (2019)
Lanthanide triflates and a series of hexadentate chiral ligand complexes were synthesized. X-ray-quality crystals were obtained from mixtures of the lanthanide complexes, which were helical in shape. The complexes showed Lewis acidity and catalyzed the enantioselective Diels–Alder reaction of electron-rich siloxydienes. The complexes were stable enough to be stored at ambient temperature on a laboratory bench and retained their Lewis acidity even after a month.
Self-assembled porphyrin-based cage complexes, M11L6 (M = ZnII, CdII), with inner coordination sites in their crystal structure
Iizuka, Fumiya,Nakamura, Takashi,Sato, Hiroyasu,Shionoya, Mitsuhiko,Ube, Hitoshi
supporting information, p. 323 - 326 (2020/04/10)
Herein we report self-assembled metallo-cage complexes, M11(L1)6 (M = ZnII, CdII), formed from 4-fold-symmetric ZnII-porphyrin-centered tetrakis-meso-(5¤-methyl-2,2¤-bipyridyl) ligands. The structures of these two D3-symmetric cages have been characterized by 1D and 2D NMR, ESI-MS, and XRD analyses. A common structural feature of these complexes is their inner molecular binding site at the axial position of each square-pyramidal ZnII-porphyrin in the crystal structure, which would provide a method to place molecular coordination sites inside or outside the cage complex with the minimum chemical modification.
MACROCYCLIC AZOLOPYRIDINE DERIVATIVES AS EED AND PRC2 MODULATORS
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Paragraph 1078, (2020/10/09)
The invention relates to modulators of Embryonic Ectoderm Development (EED) and/or Polycomb Repressive Complex 2 (PRC2) useful in the treatment of disorders and diseases associated with EEC and PRC2, being macrocyclic azolopyridine derivatives and compositions thereof of Formula (I), or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, enantiomer, isomer, or tautomer thereof, wherein X1, X2, X3, A1, A2, Y, R1, R2, R3, and R4 are as described herein.
