55478-54-1

Basic information

• Product Name: Z-DL-PHE(4-CL)-OH
• Synonyms: N-ALPHA-CARBOBENZOXY-DL-(4-CHLORO)PHENYLALANINE;Z-P-CHLORO-DL-PHE-OH;Z-DL-PHE(4-CI)-OH;Z-DL-PHE(4-CL)-OH;Z-4-CHLORO-DL-PHENYLALANINE;CBZ-DL-4-CHLOROPHENYLALANINE;4-Chloro-N-[(phenylmethoxy)carbonyl]-DL-phenylalanine;(RS)-Z-2-amino-3-(4-chlorophenyl)propionic acid
• CAS NO: 55478-54-1
• Molecular Formula: C₁₇H₁₆ClNO₄
• Molecular Weight: 333.77
• Mol File: 55478-54-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: Store at 0-5°C
• CAS DataBase Reference: Z-DL-PHE(4-CL)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-DL-PHE(4-CL)-OH(55478-54-1)
• EPA Substance Registry System: Z-DL-PHE(4-CL)-OH(55478-54-1)

Safety Data

• Hazardous Substances Data: 55478-54-1(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Upstream product

• 10466-61-2 (2S)-amino-4-methylpentanamide hydrochloride 
• 127862-82-2 Z-DL-Phe(4Cl)-OCH₂CF₃ 
• 134306-44-8 Z-DL-Phe(4Cl)OMe 
• 7424-00-2 DL-Phe(4Cl) 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 78835-68-4 {1-[2-Amino-3-(4-chloro-phenyl)-propionylamino]-ethyl}-phosphonic acid 
• 127862-82-2 Z-DL-Phe(4Cl)-OCH₂CF₃ 
• 134306-44-8 Z-DL-Phe(4Cl)OMe 
• 78835-67-3 {1-[2-Benzyloxycarbonylamino-3-(4-chloro-phenyl)-propionylamino]-ethyl}-phosphonic acid diethyl ester 

Relevant articles and documents

Superiority of the carbamoylmethyl ester as an acyl donor for the kinetically controlled amide-bond formation mediated by α-chymotrypsin

The superiority of the carbamoylmethyl ester as an acyl donor for the α-chymotrypsin-catalysed kinetically controlled peptide-bond formation is demonstrated in the couplings of an inherently poor amino acid substrate, Ala, with various amino acid residues as amino components and in the couplings of non-protein amino acids such as halogenophenylalanines as carboxylic components. Furthermore, this approach is applied to the amide-bond formation between an amino acid residue and a chiral amine, which is highly diastereoselective.

α-Chymotrypsin-catalysed peptide synthesis using activated esters as acyl donors

The coupling efficiency in α-chymotrypsin-catalysed peptide synthesis is greatly improved by the use of activated esters such as the 2,2,2-trifluoroethyl ester as acyl donor instead of the conventional methyl ester; this approach is useful for the incorporation of non-protein amino acids into peptides.

3,5-substituted 4,5-dihydroisoxazoles as transglutaminase inhibitors

The present invention is directed to certain 3,5 substituted, 4,5-dihydroisoxazoles, and methods for their use. These compounds are transgulatminase inhibitors, and are particularly effective in the inhibition of epidermal transglutaminase and the treatment of acne.