77034-33-4 Usage
Description
Ethyl piperidine-2-carboxylate hydrochloride, also known as Ethyl 2-piperidinecarboxylate hydrochloride, is a heterocyclic building block that plays a crucial role in the synthesis of various organic compounds and pharmaceuticals. It is characterized by its ability to form stable salts and its versatile chemical reactivity, making it a valuable intermediate in organic synthesis.
Uses
Used in Pharmaceutical Industry:
Ethyl piperidine-2-carboxylate hydrochloride is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to form stable salts and versatile chemical reactivity.
Used in the Preparation of 1,4-diazabicyclo[4.4.0]decane:
Ethyl piperidine-2-carboxylate hydrochloride is used as a starting material for the preparation of 1,4-diazabicyclo[4.4.0]decane, a heterocyclic compound with potential applications in various chemical and pharmaceutical processes.
Used in the Development of Small Molecule Inhibitors of Legionella MIP Protein:
Ethyl piperidine-2-carboxylate hydrochloride is used as a building block in the development of small molecule inhibitors targeting the Legionella MIP protein, which can help in the treatment of Legionnaires' disease.
Used in the Synthesis of Anti-inflammatory and Analgesic Molecules:
Ethyl piperidine-2-carboxylate hydrochloride is used as a synthetic intermediate for the creation of anti-inflammatory and analgesic molecules, contributing to the development of effective pain relief and inflammation management medications.
Used in the Development of Anti-amnesic Agents:
Ethyl piperidine-2-carboxylate hydrochloride is used as a component in the development of anti-amnesic agents, which can potentially help in the treatment of memory-related disorders and cognitive decline.
General Description:
Ethyl pipecolinate hydrochloride is a heterocyclic building block that has been reported to participate in the total synthesis of (+)-epiquinamide, a quinolizidine alkaloid with potential biological activities. Its unique structure and reactivity make it a valuable component in the synthesis of various organic compounds and pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 77034-33-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,0,3 and 4 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 77034-33:
(7*7)+(6*7)+(5*0)+(4*3)+(3*4)+(2*3)+(1*3)=124
124 % 10 = 4
So 77034-33-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H15NO2.ClH/c1-2-11-8(10)7-5-3-4-6-9-7;/h7,9H,2-6H2,1H3;1H
77034-33-4Relevant articles and documents
Multivalent manganese complex decorated amphiphilic dextran micelles as sensitive MRI probes
Wu, Changqiang,Li, Danyang,Yang, Li,Lin, Bingbing,Zhang, Houbing,Xu, Ye,Cheng, Zhuzhong,Xia, Chunchao,Gong, Qiyong,Song, Bin,Ai, Hua
supporting information, p. 1470 - 1473 (2015/03/04)
T1 contrast agents based on Mn(ii) were conjugated on amphiphilic dextran micelles via click chemistry. The obtained paramagnetic nanomicelle contrast agent has a higher T1 relaxivity (13.3 Mn mmol-1 s-1) and better sensitivity than those of free Mn(ii) complexes. Studies carried out in vivo suggest that this contrast agent has a better and long-acting vascular enhancement effect at a lower manganese dosage (0.1 Mn mmol kg-1 BW). This journal is
Base-promoted c→n acyl rearrangement: An unconventional approach to α-amino acid derivatives
Ugarriza, Iratxe,Uria, Uxue,Carrillo, Luisa,Vicario, Jose L.,Reyes, Efraim
supporting information, p. 11650 - 11654 (2014/10/15)
We have discovered that N-alkyl aminomalonates undergo a fast and selective intramolecular C→N acyl rearrangement reaction in the presence of a strong base, leading to N-protected glycinates in excellent yield. Moreover, the fact that the reaction proceeds through a nucleophilic enolate intermediate has been used for implementing a tandem rearrangement/alkylation sequence that has been applied to the preparation of synthetically relevant nonproteinogenic tertiary and quaternary N-alkyl α-amino acids in a very simple and reliable way.
A concise synthesis of (±) and a total synthesis of (+)-epiquinamide
Tong, Sok Teng (Amy),Barker, David
, p. 5017 - 5020 (2007/10/03)
A total synthesis of the quinolizidine alkaloid (+)-epiquinamide 1 has been achieved starting from (-)-pipecolinic acid 3. The key step is the highly diastereoselective addition of a TBDMS-protected propargyl alcohol to a chiral aldehyde derived from 3 to give erythro alkynol 19, which is then easily transformed into the desired bicyclic skeleton.
