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Carazolol
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Name

Carazolol

 EINECS 260-945-1
CAS No. 57775-29-8 Density 1.195 g/cm3
PSA 57.28000 LogP 3.44970
Solubility N/A Melting Point 133-137 ºC
Formula C18H22 N2 O2 Boiling Point 531.2 ºC at 760 mmHg
Molecular Weight 298.385 Flash Point 275.1 ºC
Transport Information N/A Appearance Yellowish solid
Safety 26 Risk Codes 22-36/37/38
Molecular Structure Molecular Structure of 57775-29-8 (CARAZOLOL HCL) Hazard Symbols HarmfulXn
Synonyms

(R,S)-Carazolol;(?à)-Carazolol; BM 51052; Carazolol;Conducton; DL-Carazolol; Racemic Carazolol; Suacron; Suacron Praemix

Article Data 5

Carazolol Synthetic route

75-31-0

isopropylamine

51997-51-4

4-(2,3-epoxypropoxy)carbazole

57775-29-8

carazolol

Conditions
ConditionsYield
In methanol for 6h; Reflux;63%
57775-29-8

carazolol

76-05-1

trifluoroacetic acid

C18H21ClN2O2*C2HF3O2

Conditions
ConditionsYield
With glucose dehydrogenase; alpha-D-glucopyranose; maltose binding protein-RebF; RebH variant 4-V; nicotinamide adenine dinucleotide; flavin adenine dinucleotide; sodium chloride In methanol at 25℃; for 72h; pH=7.4; Enzymatic reaction;79%
34619-03-9

tert-butyldicarbonate

57775-29-8

carazolol

A

117374-78-4

(R,S)-3-N-tert-butoxycarbonylisopropylamino-1-(carbazol-4-yloxy)-2-propanol

B

117374-79-5

(R,S)-3-N-tert-butoxycarbonylisopropylamino-2-tert-butoxycarbonyloxy-1-(carbazol-4-yloxy)propane

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane for 30h; Ambient temperature;A 78%
B 12%
57775-29-8

carazolol

98-60-2

4-chlorobenzenesulfonyl chloride

N-(3-(9H-carbazol-4-yloxy)-2-hydroxypropyl)-4-chloro-N-isopropylbenzenesulfonamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran Heating;74%
349-88-2

4-Fluorobenzenesulfonyl chloride

57775-29-8

carazolol

N-(3-(9H-carbazol-4-yloxy)-2-hydroxypropyl)-4-fluoro-N-isopropylbenzenesulfonamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran Heating;68%
57775-29-8

carazolol

122-51-0

orthoformic acid triethyl ester

129625-25-8

1,1',1''-Tris<4-(2-hydroxy-3-isopropylamino-n-propyloxy)-carbazolyl>methane

Conditions
ConditionsYield
With trichloroacetic acid In dichloromethane for 2h; Ambient temperature;26%
With trichloroacetic acid In dichloromethane for 2h; Ambient temperature;26%
57775-29-8

carazolol

106-96-7

propargyl bromide

C21H24N2O2

Conditions
ConditionsYield
Stage #1: carazolol With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.25h; Inert atmosphere;
Stage #2: propargyl bromide In N,N-dimethyl-formamide at 20℃; for 1.5h; Inert atmosphere;		7%
57775-29-8

carazolol

117374-80-8, 117374-81-9

methyl <(R,S)-3-N-tert-butoxycarbonylisopropylamino-1-(carbazol-4-yloxy)prop-2-yl-2,3,4-tri-O-acetyl-β-D-glucopyranosid>uronate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 78 percent / NaOH / dioxane / 30 h / Ambient temperature
2: 82 percent / Ag2CO3 / toluene / 96 h / Ambient temperature
View Scheme
57775-29-8

carazolol

78859-34-4

(R)-Carazolol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 78 percent / NaOH / dioxane / 30 h / Ambient temperature
2: 82 percent / Ag2CO3 / toluene / 96 h / Ambient temperature
3: 51 percent / trifluoroacetic acid / CH2Cl2 / 0.25 h
4: 93 percent / sodium methoxide / methanol / 12 h / Ambient temperature
5: β-D-glucuronidase / H2O / 72 h / 37 °C
View Scheme
Multi-step reaction with 5 steps
1: 78 percent / NaOH / dioxane / 30 h / Ambient temperature
2: 82 percent / Ag2CO3 / toluene / 96 h / Ambient temperature
3: 46 percent / trifluoroacetic acid / CH2Cl2 / 0.25 h
4: 92 percent / sodium methoxide / methanol / 12 h / Ambient temperature
5: β-D-glucuronidase / H2O / 72 h / 37 °C
View Scheme
57775-29-8

carazolol

78859-33-3

(S)-Carazolol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 78 percent / NaOH / dioxane / 30 h / Ambient temperature
2: 82 percent / Ag2CO3 / toluene / 96 h / Ambient temperature
3: 51 percent / trifluoroacetic acid / CH2Cl2 / 0.25 h
4: 93 percent / sodium methoxide / methanol / 12 h / Ambient temperature
5: β-D-glucuronidase / H2O / 72 h / 37 °C
View Scheme
Multi-step reaction with 5 steps
1: 78 percent / NaOH / dioxane / 30 h / Ambient temperature
2: 82 percent / Ag2CO3 / toluene / 96 h / Ambient temperature
3: 46 percent / trifluoroacetic acid / CH2Cl2 / 0.25 h
4: 92 percent / sodium methoxide / methanol / 12 h / Ambient temperature
5: β-D-glucuronidase / H2O / 72 h / 37 °C
View Scheme

Carazolol Chemical Properties

The molecular structure of 2-Propanol,1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]- (CAS NO.57775-29-8) is

IUPAC Name: 1-(9H-Carbazol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol 
Canonical SMILES: CC(C)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O
Molecular Formula: C18H22N2O2
Molecular Weight: 298.3795
EINECS: 260-945-1
Density: 1.195 g/cm3
Melting Point: 133-137 ºC
Boiling Point: 531.2 ºC at 760 mmHg
Flash Point: 275.1 ºC
Appearance: yellowish solid
Freely Rotating Bonds: 7
Polar Surface Area: 26.63 Å2
Index of Refraction: 1.652
Molar Refractivity: 91.26 cm3
Molar Volume: 249.5 cm3
Polarizability: 36.17 ×10-24 cm3
Surface Tension: 51.7 dyne/cm
Enthalpy of Vaporization: 84.91 kJ/mol
Vapour Pressure: 4.09E-12 mmHg at 25°C
The Cas Register Number  of 2-Propanol,1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]- is 57775-29-8. The chemical synonyms of  2-Propanol,1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]- (CAS NO.57775-29-8) are (R)-4-(2-Hydroxy-3-isopropylamino-propoxy)-carbazole ; (R)-1-(Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol ; (R,S)-Carazolol ; (R)-CarazoloL ; Carvediol ; 1-(Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol ; 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]- ; 2-Propanol, 1-(9H-Carbazol-4-yloxy)-3-[(1-methylethyl)amino], (2R) .

Carazolol Uses

 2-Propanol,1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]- (CAS NO.57775-29-8) is used as pharmaceutical intermediate .

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