Molecular Biology and Evolution (MBE) publishes research at the interface between molecular and evolutionary biology. The journal publishes investigations of molecular evolutionary patterns and processes, tests of evolutionary hypotheses that use molecular data, and studies that use molecular evolutionary information to address questions about biological function at all levels of organization. Reports of work on comparative and evolutionary genomics and the evolution of molecular structure and function are particularly welcome.

MBE is entirely owned by The Society for Molecular Biology and Evolution. The Council of the Society appoints the Editor-in-Chief. The Journal is published by Oxford University Press in conjunction with HighWire Press.