SPROUT is an effective tool for the design of drug-like, biologically active molecules. It is an interactive system that can assist in several stages of the structure-based rational drug design process.
The system is modularized and offers automatic methods for solving a number of problems in drug design. Powerfully, the user maintains control and is able to guide and modify each module for maximum versatility. SPROUT is the only de novo ligand design tool guaranteed to find all solutions within the constraints defined by the input parameters.

Functions: Detection of potential binding pockets; Identification of favourable interaction regions for various forces, including: hydrogen bonding, hydrophobic, metal ion and covalent bonding interactions; Docking of functional groups to the target sites; Building novel chemical structures by fragment joining to fulfill the chemical and steric constraints of the binding site; Scoring, sorting and clustering of the results.