- Production Method of Racecadotril
-
Racecadotril (CAS NO.: 81110-73-8), with its systematic name of Glycine, N-(2-((acetylthio)methyl)-1-oxo-3-phenylpropyl)-, phenylmethyl ester, (+-)-, could be produced through many synthetic methods.
Following is one of the synthesis routes: 2-Benzylacrylic acid (I) reacts with SOCl2 in hot toluene to afford the acyl chloride (II), which is condensed with N-tosylglycine benzyl ester (III) in the presence of TEA in toluene to yield the corresponding amide (IV). Finally, this compound is condensed with thioacetic acid by heating at 80 °C to afford the target acylthio compound.
Prev:No record
Next:No record - 【Back】【Close 】【Print】【Add to favorite 】
-
Health and Chemical more >
-
Hot Products
- 865659-12-7 Ethyl 1-(3-cyano-4,6-dimethylpyridin-2-yl)piperidine-4-carboxylate
- 18600-52-7 4H-3,1-Benzoxazin-4-one, 2-(4-chlorophenyl)-
- 496-72-0 3,4-Diaminotoluene
- 42966-64-3 N-Ethyl-1,3-dimethylbutan-1-amine
- 866152-24-1 3-[(2,6-Dichlorobenzoyl)amino]-4-methyl-2-thiophenecarboxylic acid
- 1992-48-9 TETRAISOPROPYL ORTHOSILICATE
- 68937-55-3 DIMETHYLSILOXANE, PROPYLENE OXIDE/ETHYLENE OXIDE BLOCK COPOLYMER
- 24235-06-1 DAST (stilbazolium derivative)
- 21761-08-0 trifluoroacetyl-L-lysine
- 111850-25-0 4,4',4''-(1-methylpropan-1-yl-3-ylidene)tris(2-cyclohexyl-5-methylphenol)
- 3006-93-7 N,N'-1,3-Phenylene bismaleimide
- 55965-13-4 EMULSIFIERYN