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Name	Choline Salicylate	EINECS	217-948-8
CAS No.	2016-36-6	Density	g/cm³
PSA	80.59000	LogP	-0.55940
Solubility	N/A	Melting Point	49.5-50.0°
Formula	C₇H₅O₃^.C₅H₁₄NO	Boiling Point	336.3 °C at 760 mmHg
Molecular Weight	241.287	Flash Point	144.5 °C
Transport Information	N/A	Appearance	Clear, colourless liquid
Safety	Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An analgesic and antipyretic. When heated to decomposition it emits toxic fumes of NO_x and NH₃. See also CHOLINE.	Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	(2-Hydroxyethyl)trimethylammonium salicylate	Article Data	11

Choline Salicylate Synthetic route

: 123-41-1
cholin hydroxide

: 69-72-7
salicylic acid

: 2016-36-6
choline salicylate

Conditions

Conditions	Yield
In methanol at 20℃; for 12h;	100%
at 20 - 50℃; for 2h;	98%
With OH-	98%
In ethanol; water at 25℃;
In water at 20℃; for 12h;

: 67-48-1
choline chloride

: 54-21-7
sodium salicylate

: 2016-36-6
choline salicylate

Conditions

Conditions	Yield
In acetone for 72h;	100%
In ethanol at 20℃; for 1h;

: 67-48-1
choline chloride

: 2016-36-6
choline salicylate

Conditions

Conditions	Yield
In acetone

Choline Salicylate Chemical Properties

Chemistry informtion about Choline Salicylate (CAS NO.2016-36-6) is:
IUPAC Name: 2-Hydroxybenzoate; 2-Hydroxyethyl(Trimethyl)Azanium
Synonyms: (2-Hydroxyethyl)Trimethylammoniumsalicylate ; 2-Hydroxy-N,N,N-Trimethylethanaminiumsaltwith2-Hydroxybenzoicacid(1:1) ; 2-Hydroxy-N,N,N-Trimethyl-Ethanaminiusaltwith2-Hydroxybenzoicacid(1: ; 2-Hydroxy-N,N,N-Trimethyl-Ethanaminiusaltwith2-Hydroxybenzoicacid(1:1) ; Actasal ; Arret ; Arthropan ; Artrobione
MF: C₁₂H₁₉NO₄
MW: 241.28
EINECS: 217-948-8
Flash Point: 144.5 °C
Boiling Point: 336.3 °C at 760 mmHg
Vapour Pressure: 4.45E-05 mmHg at 25°C
Enthalpy of Vaporization: 61.16 kJ/mol
Following is the molecular structure of Choline Salicylate (CAS NO.2016-36-6) is:

Choline Salicylate Uses

Choline Salicylate (CAS NO.2016-36-6) was used for temporary relief of pain of rheumatoid arthritis, rheumatic fever, osteoarthritis, and other conditions for which oral salicylates are recommended; useful in patients in which there is difficulty in administering doses in a tablet or capsule dosage form, because of the liquid dosage form.

Choline Salicylate Toxicity Data With Reference

1.	orl-mus LD50:2690	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),291.
2.	ipr-mus LD50:410 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),291.
3.	scu-mus LD50:1 g/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),291.

Choline Salicylate Consensus Reports

Reported in EPA TSCA Inventory.

Choline Salicylate Safety Profile

Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An analgesic and antipyretic. When heated to decomposition it emits toxic fumes of NO_x and NH₃. See also CHOLINE.
Safty information about Choline Salicylate (CAS NO.2016-36-6) :
WGK Germany: 2
RTECS: GA6475000
F:
F 3: Hygroscopic.
F 10 Keep under argon.

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