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| Name |
Coumermycin A1 |
EINECS | N/A |
| CAS No. | 4434-05-3 | Density | 1.1866 (rough estimate) |
| PSA | 354.89000 | LogP | 5.71790 |
| Solubility | N/A | Melting Point |
259°C (rough estimate) |
| Formula | C55H59N5O20 | Boiling Point | 821.5°C (rough estimate) |
| Molecular Weight | 1110.19 | Flash Point | N/A |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. | Risk Codes | R22 |
| Molecular Structure |
|
Hazard Symbols | 470805 |
| Synonyms |
Notomycin;l)oxy)-4-hydroxy-8-methylcoumarin);notomycina1;Sugordomycin D-la;Coumermycin;COUMERMYCIN A1;coumamycin;coumermycins;Cumamycin; |
Coumermycin A1 Chemical Properties
IUPAC Name: [(3R,4S,5R)-5-Hydroxy-6-[2-hydroxy-3-[[4-[[2-hydroxy-7-[(3R,4S,5R)-3-hydroxy-5-methoxy-6,6-dimethyl-4-(5-methyl-1H-pyrrole-2-carbonyl)oxyoxan-2-yl]oxy-8-methyl-4-oxochromen-3-yl]carbamoyl]-3-methyl-1H-pyrrole-2-carbonyl]amino]-8-methyl-4-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] 5-methyl-1H-pyrrole-2-carboxylate
Synonyms of Coumermycin A1 (CAS NO.4434-05-3) : 1H-Pyrrole-2,4-dicarboxamide, N,N'-bis[7-[[6-deoxy-5-C-methyl-4-O-methyl-3-O-[(5-methyl-1H-pyrrol-2-yl)carbonyl]-.alpha.-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-3-meth ; 5-Methylpyrrole-2-carboxylic Acid Diester With 3,3'-((3-Methylpyrrole-2,4-diyl)bis(carbonylimino))bis(4-hydroxy-8-methyl-7-((tetrahydro-3,4-dihydroxy-5-methoxy-6,6-dimethylpyran-2-yl)oxy)coumarin) ; 5-Methylpyrrole-2-carboxylic Acid Diester with 3,3'-((3-Methylpyrrole-2,4-diyl)bis(carbonylimino))bis(7-((5,5-di-C-methyl-4-O-methyl-a-L-lyxopyranosyl)oxy)-4-hydroxy-8-methylcoumarin) ; Coumermycin ; Coumermycin A1
Antibiotics;Antibiotics A to;Antibiotics A-FAntibiotics;Antibiotics by Application;Chemical Structure Class;Coumarin-glycosidesAntibiotics;Genetic Marker SelectionAntibiotics;Inhibits an EnzymeAntibiotics;Interferes with DNA Synthesis;Mechanism of Action
CAS NO: 4434-05-3
Molecular Formula:C55H59N5O20
Molecular Weight :1110.0785
Molecular Structure :
Index of Refraction:1.684
Surface Tension: 85.4 dyne/cm
Density: 1.54 g/cm3
Solubility: DMSO: 50 mg/mL, clear, faintly yellow
Coumermycin A1 Uses
Coumermycin A1 (CAS NO.4434-05-3) is primarily for the treatment of intestinal infection. Ointment for the treatment of skin and wound infections.
Coumermycin A1 Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 500mg/kg (500mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 147, 1978. | |
| mouse | LD50 | intraperitoneal | 159mg/kg (159mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 147, 1978. | |
| mouse | LD50 | intravenous | 25mg/kg (25mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 147, 1978. | |
| mouse | LD50 | oral | 2gm/kg (2000mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 147, 1978. | |
| mouse | LD50 | subcutaneous | 250mg/kg (250mg/kg) | Antimicrobial Agents and Chemotherapy Vol. -, Pg. 786, 1965. |
Coumermycin A1 Safety Profile
Poison by subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes
Xn
Risk Statements 22
R22: Coumermycin A1 (CAS NO.4434-05-3) is harmful if swallowed.
Safety Statements 36
S36:Wear suitable protective clothing.
WGK Germany 3
RTECS UX9375000
F 10-21
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