The Cyclopamine is an organic compound with the formula C27H41NO2. The IUPAC name of this chemical is (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol. With the CAS registry number 4449-51-8, it is also named as 11-Deoxojervine. The product's categories are Intermediates & Fine Chemicals; Pharmaceuticals; Steroids; Lipid Signaling. Besides, it is a white crystalline solid, which should be stored in a dark dry and well-ventilated place.
The Cyclopamine can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by suppressing the hedgehog gene (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.
Physical properties about Cyclopamine are: (1)ACD/LogP: 6.10; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 3.005; (4)ACD/LogD (pH 7.4): 3.263; (5)ACD/BCF (pH 5.5): 20.45; (6)ACD/BCF (pH 7.4): 37.05; (7)ACD/KOC (pH 5.5): 39.815; (8)ACD/KOC (pH 7.4): 72.134; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 41.49 Å2; (13)Index of Refraction: 1.583; (14)Molar Refractivity: 120.716 cm3; (15)Molar Volume: 360.973 cm3; (16)Polarizability: 47.856×10-24cm3; (17)Surface Tension: 46.114 dyne/cm; (18)Density: 1.14 g/cm3; (19)Flash Point: 286.91 °C; (20)Enthalpy of Vaporization: 95.514 kJ/mol; (21)Boiling Point: 550.794 °C at 760 mmHg.
You can still convert the following datas into molecular structure:
(1)SMILES: C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5CC4=C3C)C)O)C)NC1
(2)InChI: InChI=1/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1
(3)InChIKey: QASFUMOKHFSJGL-LAFRSMQTBZ
(4)Std. InChI: InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1
(5)Std. InChIKey: QASFUMOKHFSJGL-LAFRSMQTSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
hamster | LDLo | oral | 170mg/kg (170mg/kg) | | Proceedings of the Society for Experimental Biology and Medicine. Vol. 149, Pg. 302, 1975. |
mouse | LDLo | oral | 180mg/kg (180mg/kg) | | Proceedings of the Society for Experimental Biology and Medicine. Vol. 149, Pg. 302, 1975. |