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Cyclosarin

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Name

Cyclosarin

EINECS N/A
CAS No. 329-99-7 Density 1.09g/cm3
PSA 36.11000 LogP 3.12810
Solubility N/A Melting Point -30oC
Formula C7H14 F O2 P Boiling Point 237.2°Cat760mmHg
Molecular Weight 180.159 Flash Point 97.3°C
Transport Information N/A Appearance N/A
Safety A deadly poison by subcutaneous route. When heated to decomposition it emits toxic fumes of POx and F. Risk Codes N/A
Molecular Structure Molecular Structure of 329-99-7 (cyclohexyl methylphosphonofluoridate) Hazard Symbols N/A
Synonyms

Phosphonofluoridicacid, methyl-, cyclohexyl ester (6CI,7CI,8CI,9CI); CMPF; Cyclohexylmethylphosphonofluoridate; Cyclosarin; Cyclosin; Cyclosin (chemical warfareagent); GF; GF (chemical warfare agent); Methyl cyclohexylfluorophosphonate;O-Cyclohexyl methylphosphonofluoridate

 

Cyclosarin Chemical Properties

The IUPAC name of Cyclosarin (CAS NO.329-99-7):
 [Fluoro(methyl)phosphoryl]oxycyclohexane
Synonyms: Cyclohexyl methylphosphonofluoridate ; O-cyclohexyl-methylphosphonofluoridate ; Agentgf ; Methyl cyclohexylfluorophosphonate
CAS: 329-99-7 
Molecular Weight: 180.157024 g/mol
Molecular Formula: C7H14FO2
Molecular Structure:

Index of Refraction: 1.414 
Density: 1.09 g/cm
Flash Point: 97.3 °C 
Boiling Point: 237.2 °C at 760 mmHg 
Air & Water Reactions:Likely hydrolyzed by water, rapidly hydrolyzed by dilute aqueous sodium hydroxide

Cyclosarin Production

Reactivity Profile: Acidic conditions produce hydrogen fluoride; alkaline conditions produce isopropyl alcohol and polymers. When heated to decomposition or reacted with steam, cyclohexyl methylphosphonofluoridate emits very toxic fumes of fluorides and oxides of phosphorus. Slightly corrosive to steel. Hydrolyzed by water.

Cyclosarin Toxicity Data With Reference

The toxicity of Cyclosarin (CAS NO.329-99-7):

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 subcutaneous 100ug/kg (0.1mg/kg)   Canadian Journal of Physiology and Pharmacology. Vol. 44, Pg. 745, 1966.
hamster LD50 subcutaneous 130ug/kg (0.13mg/kg)   Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968.
mouse LD50 subcutaneous 400ug/kg (0.4mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA

GASTROINTESTINAL: NAUSEA OR VOMITING
Science Journal. Vol. 3(4), Pg. 33, 1967.
rabbit LD50 subcutaneous 100ug/kg (0.1mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: COMA
Science Journal. Vol. 3(4), Pg. 33, 1967.
rat LD50 intramuscular 80ug/kg (0.08mg/kg)   Pharmacology and Toxicology Vol. 84, Pg. 41, 1999.
rat LD50 subcutaneous 225ug/kg (0.225mg/kg)   Canadian Journal of Physiology and Pharmacology. Vol. 44, Pg. 745, 1966.

Cyclosarin Safety Profile

The safety information of Cyclosarin (CAS NO.329-99-7):
A deadly poison by subcutaneous route. When heated to decomposition it emits toxic fumes of POx and F.
Health Hazard: Median lethal dose (mg-min/m3): 2500 by skin (vapor) or 350 (liquid); 35 inhaled. Median incapacitating dose: 25 inhaled. Eye/skin toxicity: Very high. Rate of action: Very rapid. Physiological action: Cessation of breath-death may follow. Detoxification rate: Low. (ANSER)

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