Basic Information | Post buying leads | Suppliers |
Name |
DITRAN |
EINECS | N/A |
CAS No. | 8015-54-1 | Density | N/A |
PSA | N/A | LogP | N/A |
Solubility | N/A | Melting Point |
N/A |
Formula | C20H29NO3•C20H29NO3•2ClH | Boiling Point | 458.8°C at 760 mmHg |
Molecular Weight | 735.92 | Flash Point | 231.3°C |
Transport Information | N/A | Appearance | N/A |
Safety | Poison by intravenous, intraperitoneal, and intramuscular routes. Human systemic effects by ingestion and intramuscular routes: visual field changes, hallucinations, distorted perceptions, nausea and vomiting. When heated to decomposition it emits toxic fumes of NOx and Cl−. | Risk Codes | N/A |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
Ditran |
IUPAC Name: (1-Ethylpyrrolidin-2-yl)methyl 2-cyclopentyl-2-hydroxy-2-phenylacetate dihydrochloride
Synonyms of DITRAN (CAS NO.8015-54-1) : 1-Ethyl-3-piperidyl alpha-cyclopentyl-alpha-phenylglycolate hydrochloride ; Mandelic acid, alpha-cyclopentyl-, 1-ethyl-3-piperidyl ester, hydrochloride, mixed with (1-ethyl-2-pyrrolidinyl)methyl alpha-cyclopentylmandelate hydrochloride
InChI:InChI=1/2C20H29NO3.2ClH/c2*1-2-21-14-8-13-18(21)15-24-19(22)20(23,17-11-6-7-12-17)16-9-4-3-5-10-16;;/h2*3-5,9-10,17-18,23H,2,6-8,11-15H2,1H3;2*1H
CAS NO:8015-54-1
Molecular Formula:C40H60Cl2N2O6
Molecular Weight :735.8202
Molecular Structure :
Flash Point: 231.3 °C
Enthalpy of Vaporization: 75.78 kJ/mol
Boiling Point: 458.8 °C at 760 mmHg
Vapour Pressure: 3.27E-09 mmHg at 25°C
Ditran was developed during chemical weapons research in an attempt to produce non-lethal incapacitating agents, similar to QNB itself. The ditran mixture is more potent as an anticholinergic than the piperidyl benzilate drugs such as N- methyl- 3 -piperidyl benzilate, but is less potent than QNB.
DITRAN (CAS NO.8015-54-1) is an anticholinergic drug mixture, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB).
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | intravenous | 45mg/kg (45mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 224, 1972. | |
human | TDLo | intramuscular | 100ug/kg (0.1mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | "Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents," National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85Vol. 1, Pg. L1, 1982. |
human | TDLo | oral | 40ug/kg (0.04mg/kg) | SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" GASTROINTESTINAL: NAUSEA OR VOMITING | Journal of Nervous and Mental Disease. Vol. 131, Pg. 428, 1960. |
man | TDLo | intramuscular | 150ug/kg (0.15mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 32, Pg. 250, 1973. |
mouse | LD50 | intraperitoneal | 60mg/kg (60mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 224, 1972. | |
mouse | LD50 | intravenous | 10mg/kg (10mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 224, 1972. | |
mouse | LD50 | oral | 300mg/kg (300mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: EXCITEMENT BEHAVIORAL: IRRITABILITY | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1727, 1971. |
rabbit | LD50 | intravenous | 12mg/kg (12mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 224, 1972. | |
rat | LD50 | intraperitoneal | 25mg/kg (25mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 224, 1972. | |
rat | LD50 | intravenous | 19mg/kg (19mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 224, 1972. |
Poison by intravenous, intraperitoneal, and intramuscular routes. Human systemic effects by ingestion and intramuscular routes: visual field changes, hallucinations, distorted perceptions, nausea and vomiting. When DITRAN (CAS NO.8015-54-1) is heated to decomposition, it emits toxic fumes of NOx and Cl−.