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Darvon-N
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Name

Darvon-N

 EINECS N/A
CAS No. 26570-10-5 Density g/cm3
PSA 101.52000 LogP 7.37850
Solubility N/A Melting Point N/A
Formula C10H8O3S•C22H29NO2•H2O Boiling Point 444°Cat760mmHg
Molecular Weight 565.731 Flash Point 130.6°C
Transport Information N/A Appearance N/A
Safety Poison by ingestion, subcutaneous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SOx and NOx. See also d-PROPOXYPHENE HYDROCHLORIDE and SULFONATES. Risk Codes N/A
Molecular Structure Molecular Structure of 26570-10-5 (DEXTROPROPOXYPHENE NAPSYLATE HYDRATE) Hazard Symbols 3
Synonyms

d-PROPOXYPHENE NAPSYLATE HYDRATE;S-9700;d-4-DIMETHYLAMINO-3-METHYL-1,2-DIPHENYL-2-PROPIONOXYBUTANENAPHTHALENE-2-SULPHONATE HYDRATE;

 

Darvon-N Chemical Properties

IUPAC Name: [(2S,3R)-4-(Dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate; naphthalene-2-sulfonic acid; hydrate
Synonyms of Darvon-N (CAS NO.26570-10-5) : (+)- Propoxyphene napsylate ; 2-Naphthalenesulfonic Acid compound with (aS)-a-((1R)-2-(Dimethylamino)-1-methylethyl)-a-phenylbenzeneethanol Propanoate (1:1) Monohydrate ; Doloxene ; Naphthalene-2-sulfonic acid - (2S,3R)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl propanoate hydrate (1:1:1) ; Propoxyphene Napsylate (anhydrous)
InChI:InChI=1/C22H29NO2.C10H8O3S.H2O/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19;11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10;/h6-15,18H,5,16-17H2,1-4H3;1-7H,(H,11,12,13);1H2/t18-,22+;;/m1../s1
CAS NO:26570-10-5
Molecular Formula:C32H39NO6S            
Molecular Weight :565.7202               
Molecular Structure :
Flash Point: 130.6 °C 
Enthalpy of Vaporization: 70.17 kJ/mol 
Boiling Point: 444 °C at 760 mmHg 
Vapour Pressure: 4.43E-08 mmHg at 25°C 

Darvon-N Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 100mg/kg (100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

GASTROINTESTINAL: NAUSEA OR VOMITING		 Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971.
cat LDLo subcutaneous 800mg/kg (800mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

GASTROINTESTINAL: NAUSEA OR VOMITING		 Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971.
dog LDLo oral 800mg/kg (800mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971.
dog LDLo subcutaneous 1200mg/kg (1200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA		 Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971.
guinea pig LDLo oral 400mg/kg (400mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA		 Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971.
guinea pig LDLo subcutaneous 800mg/kg (800mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA		 Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971.
mouse LD50 intraperitoneal 171mg/kg (171mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971.
mouse LD50 oral 973mg/kg (973mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 359, 1971.
mouse LD50 subcutaneous 749mg/kg (749mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1011, 1971.
rabbit LDLo oral 800mg/kg (800mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971.
rat LD50 intraperitoneal 56mg/kg (56mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1011, 1971.
rat LD50 oral 485mg/kg (485mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1011, 1971.
rat LD50 subcutaneous 169mg/kg (169mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1011, 1971.

Darvon-N Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. When Darvon-N (CAS NO.26570-10-5) is heated to decomposition ,it emits toxic fumes of SOx and NOx. See also d-PROPOXYPHENE HYDROCHLORIDE and SULFONATES.

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