An extract from calf blood containing inorganic salts, amino acids, polypeptides and purines, but no proteins nor antigenic substances or blood group characteristics. Its exact composition is unknown. It has been proposed as a radiation-protective agent.
Product Name: Deproteinized serum
Synonyms of Deproteinized serum (CAS NO.68070-90-6): Blood, exts

 Deproteinized serum (CAS NO.68070-90-6) is often used as a rapid method for analysis of drugs and small molecules in serum in HPLC.

Poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Experimental reproductive effects.

Reversed-phase liquid chromatography was investigated for the determination of anticonvulsants by direct injection of deproteinized serum (CAS NO.68070-90-6). Octyl modified silica (RP-8) as stationary phase and phosphate buffer (0.1M pH=3.0) — butanol 92∶8 (v/v) as mobile phase was found suitable for the simultaneous determination of primidone, phenobarbital, carbamazepine and diphenyl hydantoine directly in deproteinized sera from patients. Anticonvulsants like sulthiam, phenyl ethyl malondiamide, ethyl methyl succinimide and the epoxide metabolite of carbamazepine cannot be determined in this way because of disturbance by the serum background. It is shown that the analytical column can be used for on-column concentration of anticonvulsants with 1 cm³ deproteinized serum. The technique proved to be suitable for the determination of phenytoine-3-norvaline in serum.