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Di-tert-butyl N,N-diisopropylphosphoramidite

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Name

Di-tert-butyl N,N-diisopropylphosphoramidite

EINECS N/A
CAS No. 137348-86-8 Density 0.879 g/cm3
PSA 35.29000 LogP 4.96230
Solubility N/A Melting Point 85-90 °C 0.2 mm Hg(lit.)
Formula C14H32NO2P Boiling Point 252.2 °C at 760 mmHg
Molecular Weight 277.387 Flash Point 106.4 °C
Transport Information N/A Appearance Clear Colourless Liquid
Safety 26-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 137348-86-8 (Di-tert-butyl N,N-diisopropylphosphoramidite) Hazard Symbols IrritantXi
Synonyms

Phosphoramidousacid, bis(1-methylethyl)-, bis(1,1-dimethylethyl) ester (9CI);Di-tert-butylN,N-diisopropylphosphoramidite;di-tert-butyl dipropan-2-ylphosphoramidoite;phosphoramidous acid, N,N-bis(1-methylethyl)-, bis(1,1-dimethylethyl) ester;

Article Data 4

Di-tert-butyl N,N-diisopropylphosphoramidite Specification

The Di-tert-butyl N,N-diisopropylphosphoramidite, with the CAS registry number 137348-86-8, has the systematic name of di-tert-butyl dipropan-2-ylphosphoramidoite. It is a kind of clear colourless liquid, and belongs to the following product categories: Phospholipids - 13C & 2H; Phosphorylating and Phosphitylating Agents; Catalysis and Inorganic Chemistry; Phosphine Ligands; Phosphorus Compounds. And the molecular formula of the chemical is C14H32NO2P.

The characteristics of Di-tert-butyl N,N-diisopropylphosphoramidite are as followings: (1)ACD/LogP: 5.72; (2)# of Rule of 5 Violations: 1; (3)#H bond acceptors: 3; (4)#H bond donors: 0; (5)#Freely Rotating Bonds: 7; (6)Polar Surface Area: 35.29 Å2 ; (7)Flash Point: 106.4 °C; (8)Enthalpy of Vaporization: 48.96 kJ/mol; (9)Boiling Point: 252.2 °C at 760 mmHg; (10)Vapour Pressure: 0.0195 mmHg at 25°C. 

Preparation of Di-tert-butyl N,N-diisopropylphosphoramidite: This chemical can be prepared by 2-methyl-propan-2-ol and (tert-Butoxy)bis(diisopropylamino)phosphine. The reaction will need reagent diisopropylammonium tetrazolide. The reaction time is 3 hours, and the yield is about 58%.

You should be cautious while dealing with this chemical. It irritates to eyes, respiratory system and skin. Therefore, you had better take the following instructions: Wear suitable protective clothing, and if in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: O(P(OC(C)(C)C)N(C(C)C)C(C)C)C(C)(C)C
(2)InChI: InChI=1/C14H32NO2P/c1-11(2)15(12(3)4)18(16-13(5,6)7)17-14(8,9)10/h11-12H,1-10H3
(3)InChIKey: YGFLCNPXEPDANQ-UHFFFAOYAB

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