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Cas Database

Name	Dienogestrel	EINECS	639-448-2
CAS No.	65928-58-7	Density	1.2 g/cm³
PSA	61.09000	LogP	3.83718
Solubility	N/A	Melting Point	210-214 °C
Formula	C₂₀H₂₅NO₂	Boiling Point	549 °C at 760 mmHg
Molecular Weight	311.424	Flash Point	285.8 °C
Transport Information	N/A	Appearance	Pale yellow solid
Safety		Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	17a-Cyanomethyl-17b-hydroxyestra-4, 9-dien-3-one;Dienogest;Dienogestril;Dinagest;19-Norpregna-4,9-diene-21-nitrile,17-hydroxy-3-oxo-, (17a)-;	Article Data	17

Dienogestrel Chemical Properties

IUPAC Name: 2-[(8S,13S,14S,17R)-17-Hydroxy-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]acetonitrile
Molecular Formula: C₂₀H₂₅NO₂
Molecular Weight: 311.418000 g/mol
XLogP3-AA: 1.8
H-Bond Donor: 1
H-Bond Acceptor: 3
Canonical SMILES: CC12CCC3=C4CCC(=O)C=C4CCC3C1CCC2(CC#N)O
Isomeric SMILES: C[C@]12CCC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@]2(CC#N)O
InChI: InChI=1S/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/m1/s1
InChIKey: AZFLJNIPTRTECV-FUMNGEBKSA-N
Appearance: Pale Yellow Solid
Product Categories: Intermediates & Fine Chemicals; Pharmaceuticals; Steroids
Classification Code: Antineoplastic Agents; Antineoplastic agents, hormonal; Contraceptive Agents; Contraceptive Agents, Female; Contraceptive agents, male; Contraceptives, oral; Hormone; Hormone antagonists; Hormone replacement therapy; Hormones, Hormone Substitutes, and Hormone Antagonists; Mutation data; Oral contraceptive; Reproductive Control Agents; Reproductive Effect
Index of Refraction: 1.589
Molar Refractivity: 87.18cm³
Molar Volume: 258.6 cm³
Surface Tension: 52.8 dyne/cm
Density: 1.2 g/cm³
Flash Point: 285.8 °C
Enthalpy of Vaporization: 95.27 kJ/mol
Boiling Point: 549 °C at 760 mmHg
Vapour Pressure: 2.42E-14 mmHg at 25 °C
Melting Point: 210-214 °C
Water Solubility of STS 557 (CAS NO.65928-58-7): 57.88 mg/L at 25 °C

Dienogestrel Uses

STS 557 (CAS NO.65928-58-7) can be used as pharmaceutical raw material and intermediate, also used as a medicine in the treatment of endometriosis.

Dienogestrel Toxicity Data With Reference

1.	dlt-mus-scu 700 mg/kg/35D	ENDKAC Endokrinologie. 76 (1980),13.
2.	orl-mus TDLo:500 mg/kg (female 13-17D post):TER	EXCEDS Experimental and Clinical Endocrinology. 81 (1983),197.
3.	orl-mus LD50:4000 mg/kg	PHARAT Pharmazie. 34 (1979),319.
4.	ipr-mus LDLo:1 g/kg	EXCEDS Experimental and Clinical Endocrinology. 81 (1983),175.
5.	scu-mus LDLo:5000 mg/kg	PHARAT Pharmazie. 34 (1979),319.
6.	orl-rbt LDLo:1 g/kg	EXCEDS Experimental and Clinical Endocrinology. 81 (1983),175.
7.	ipr-rbt LDLo:1500 mg/kg	EXCEDS Experimental and Clinical Endocrinology. 81 (1983),175.

Dienogestrel Consensus Reports

Cyanide and its compounds are on the Community Right-To-Know List. EPA Genetic Toxicology Program.

Dienogestrel Safety Profile

Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x and CN⁻.

Dienogestrel Specification

STS 557 with CAS registry number of 65928-58-7 is pale yellow solid, known as Dienogest ; Dienogest [INN] ; 17-alpha-Cyanomethyl-17-beta-hydroxy-estra-4,9(10)-dien-3-one ; 17-alpha-Cyanomethyl-17-beta-hydroxyestra-4,9(10)-diene-3-one ; 17alpha-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile ; 17-Hydroxy-3-oxo-19-nor-17alpha-pregna-4,9-diene-21-nitrile ; 19-Norpregna-4,9-diene-21-nitrile, 17-hydroxy-3-oxo-, (17alpha)- ; Dienogestum .

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