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Dihydrofuran-3(2H)-one

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Name

Dihydrofuran-3(2H)-one

EINECS 805-925-0
CAS No. 22929-52-8 Density 1.128 g/cm3
PSA 26.30000 LogP -0.02420
Solubility N/A Melting Point N/A
Formula C4H6O2 Boiling Point 151.1 °C at 760 mmHg
Molecular Weight 86.0904 Flash Point 56.3 °C
Transport Information N/A Appearance WHITE
Safety 16-26-36/37/39-23 Risk Codes 11-19-36/37/38-22
Molecular Structure Molecular Structure of 22929-52-8 (Dihydrofuran-3(2H)-one) Hazard Symbols HarmfulXn
Synonyms

3-Oxotetrahydrofuran;Dihydro-3(2H)-furanone;Dihydrofuran-3-one;Oxolan-3-one;

Article Data 39

Dihydrofuran-3(2H)-one Synthetic route

453-20-3

3-Hydroxytetrahydrofuran

22929-52-8

tetrahydrofuran-3-one

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid In dichloromethane at -5 - 20℃; for 1h; Solvent;95%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid In dichloromethane at -5 - 20℃; for 1h; Solvent;95%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid In dichloromethane at -5 - 20℃; for 1h; Solvent;95%
57595-23-0

methyl 4-oxotetrahydrofuran-3-carboxylate

22929-52-8

tetrahydrofuran-3-one

Conditions
ConditionsYield
With sulfuric acid at 100℃; for 3h; Reagent/catalyst; Temperature;90.7%
In sulfuric acid6.8 g (79%)
89898-51-1

ethyl tetrahydrofuran-3-one 4-carboxylate

22929-52-8

tetrahydrofuran-3-one

Conditions
ConditionsYield
With sulfuric acid at 80℃; for 5h; Reagent/catalyst;82.3%
1191-99-7

2,3-dihydro-2H-furan

A

22929-52-8

tetrahydrofuran-3-one

20245-14-1, 52911-58-7, 138610-15-8

RS(SR)-2,3-dibromotetrahydrofuran

trans-3-bromo-2-hydroxytetrahydrofuran

Conditions
ConditionsYield
With water; oxygen; lithium bromide; copper(ll) bromide In tetrahydrofuran at 25℃; under 760.051 Torr;A 15%
B 75%
C 10%
29212-66-6

3-hydroxyfuran

22929-52-8

tetrahydrofuran-3-one

Conditions
ConditionsYield
Stage #1: 3-hydroxyfuran With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide In dichloromethane; water ice-water bath;
Stage #2: With sodium hypochlorite; sodium hydrogencarbonate In dichloromethane; water at 0 - 5℃; for 2.66667h;
67%
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide In dichloromethane at 0 - 5℃; for 2.66667h; pH=9.5;67%
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide In dichloromethane; water at 0 - 5℃; for 2.66667h; pH=9.5;67%
(+-)-tetrahydro-furan-3-ol

(+-)-tetrahydro-furan-3-ol

22929-52-8

tetrahydrofuran-3-one

Conditions
ConditionsYield
With copper oxide-chromium oxide catalyst at 200 - 250℃;
With sodium dichromate; diethyl ether; sulfuric acid
1191-99-7

2,3-dihydro-2H-furan

A

22929-52-8

tetrahydrofuran-3-one

B

1120-74-7, 29120-51-2, 29307-02-6

(2S,3S)-3-chlorotetrahydrofuran-2-ol

C

(2R,3R)-3-chlorotetrahydrofuran-2-ol

2-chloro-3-hydroxytetrahydrofuran

Conditions
ConditionsYield
With (R)-2,2'-bis[bis(3-methylphenyl)phosphino]-1,1'-binaphthyl; copper dichloride; palladium (II) ion Title compound not separated from byproducts;
1708-29-8

2,5-dihydrofuran

22929-52-8

tetrahydrofuran-3-one

Conditions
ConditionsYield
With dinitrogen monoxide In benzene at 220℃; for 12h; pressure;
927-74-2

1-butyn-4-ol

22929-52-8

tetrahydrofuran-3-one

Conditions
ConditionsYield
With 5-bromo-2-methyl-pyridine-N-oxide; [BrettPhosAu]NTf2; trifluoroacetic acid In 1,2-dichloro-ethane at 20℃; for 6h; Inert atmosphere; Darkness;42 %Spectr.
22929-52-8

tetrahydrofuran-3-one

1950-68-1

4-methoxybenzenesulfonyl hydrazide

1510865-64-1

N'-(dihydrofuran-3(2H)-ylidene)-4-methoxybenzene-sulfonohydrazide

Conditions
ConditionsYield
In methanol at 20℃; Schlenk technique;100%

Dihydrofuran-3(2H)-one Specification

The Dihydrofuran-3(2H)-one, with CAS registry number 22929-52-8, belongs to the following product categories: (1)Carbonyl Compounds; (2)Heterocycles. It has the systematic name of dihydrofuran-3(2H)-one. And its IUPAC name is oxolan-3-one. And the chemical formula of this chemical is C4H6O2.

Physical properties of Dihydrofuran-3(2H)-one: (1)ACD/LogP: -1.15; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.14; (4)ACD/LogD (pH 7.4): -1.14; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 5.68; (8)ACD/KOC (pH 7.4): 5.68; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 26.3 Å2; (13)Index of Refraction: 1.442; (14)Molar Refractivity: 20.18 cm3; (15)Molar Volume: 76.2 cm3; (16)Polarizability: 8×10-24cm3; (17)Surface Tension: 35.4 dyne/cm; (18)Enthalpy of Vaporization: 38.8 kJ/mol; (19)Vapour Pressure: 3.72 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
The Dihydrofuran-3(2H)-one is highly flammable, so keep it away from sources of ignition. This chemical may form explosive peroxides. And it is also harmful if swallowed. When use it, wear suitable protective clothing, gloves and eye/face protection and do not breathe vapour. If contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C1COCC1
(2)InChI: InChI=1/C4H6O2/c5-4-1-2-6-3-4/h1-3H2
(3)InChIKey: JLPJFSCQKHRSQR-UHFFFAOYAJ
(4)Std. InChI: InChI=1S/C4H6O2/c5-4-1-2-6-3-4/h1-3H2
(5)Std. InChIKey: JLPJFSCQKHRSQR-UHFFFAOYSA-N

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