Basic Information | Post buying leads | Suppliers | Cas Database |
Name |
Endomorphin 1 |
EINECS | N/A |
CAS No. | 189388-22-5 | Density | 1.343 g/cm3 |
PSA | 183.64000 | LogP | 3.79490 |
Solubility | N/A | Melting Point |
144-146℃ |
Formula | C34H38N6O5 | Boiling Point | 1052.765 °C at 760 mmHg |
Molecular Weight | 610.713 | Flash Point | 590.491 °C |
Transport Information | N/A | Appearance | Solid. (Solid powder.) |
Safety | Risk Codes | N/A | |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
L-Tyrosyl-L-prolyl-L-tryptophyl-L-phenylalaninamide; |
Article Data | 9 |
Formula :C34H38N6O5
M.W. 610.7
Solubility:soluble in water.
Chemcial structure:
Endomorphin-1 (EM-1) should be stored at -20°C. Keep container tightly closed.Endomorphin-1 (189388-22-5) is a recently isolated endogenous peptide having potent analgesic activity and high affinity and selectivity for the mu-opioid receptor. Endomorphin-1 (189388-22-5) activates G proteins and inhibits adenylyl cyclase activity in membrane preparations from cells stably expressing the mu opioid receptor, an effect reversed by the mu receptor antagonist CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2) . However, Endomorphin-1 appears to have no influence on cells stably expressing the delta opioid receptor.
Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2) are tetrapeptides with the highest known affinity and specificity for the μ opioid receptor.Endomorphin-1 is located in the nucleus of the solitary tract, the periventricular hypothalamus, and the dorsomedial hypothalamus, where it is found within histaminergic neurons and may regulate sedative and arousal behaviors.