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Cas Database |
| Name |
Ethyl 5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl) benzofuran-2-carboxylate |
EINECS | N/A |
| CAS No. | 163521-11-7 | Density | 1.29 |
| PSA | 85.50000 | LogP | 5.11028 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C28H30N4O3 | Boiling Point | 687.8±55.0 °C(Predicted) |
| Molecular Weight | 470.571 | Flash Point | N/A |
| Transport Information | N/A | Appearance | N/A |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazi; |
Article Data | 5 |
Ethyl 5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl) benzofuran-2-carboxylate Synthetic route
- 143612-79-7
3-(4-chlorobutyl)-5-cyanoindole
- 163521-11-7
5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl)benzofuran-2-carboxylic acid ethyl ester
| Conditions | Yield |
|---|---|
| With potassium carbonate In acetonitrile | 32% |
| With potassium carbonate; triethylamine In acetonitrile for 12h; Heating; |
- 15861-24-2
1H-indole-5-carbonitrile
- 163521-11-7
5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl)benzofuran-2-carboxylic acid ethyl ester
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 73 percent / isobutyl-AlCl2 / CH2Cl2 / 15 - 30 °C 2: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 3: K2CO3; Et3N / acetonitrile / 12 h / Heating View Scheme | |
| Multi-step reaction with 3 steps 1: isobutylaluminum dichloride / dichloromethane 2: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran 3: potassium carbonate / acetonitrile View Scheme |
- 69604-00-8
ethyl 5-nitrobenzo[d]furan-2-carboxylate
- 163521-11-7
5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl)benzofuran-2-carboxylic acid ethyl ester
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 93 percent / H2 / Raney Ni / methanol / 27 h / 28 °C 2: 27 percent / K2CO3 / butan-1-ol / 48 h / Heating 3: K2CO3; Et3N / acetonitrile / 12 h / Heating View Scheme |
- 174775-48-5
ethyl 5-amino-1-benzofuran-2-carboxylate
- 163521-11-7
5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl)benzofuran-2-carboxylic acid ethyl ester
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 27 percent / K2CO3 / butan-1-ol / 48 h / Heating 2: K2CO3; Et3N / acetonitrile / 12 h / Heating View Scheme |
- 276863-95-7
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
- 163521-11-7
5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl)benzofuran-2-carboxylic acid ethyl ester
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; Et3N / acetonitrile / 12 h / Heating View Scheme | |
| Multi-step reaction with 2 steps 1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran 2: potassium carbonate / acetonitrile View Scheme |
- 143612-79-7
3-(4-chlorobutyl)-5-cyanoindole
- 163521-11-7
5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl)benzofuran-2-carboxylic acid ethyl ester
| Conditions | Yield |
|---|---|
| With tetra-(n-butyl)ammonium iodide; potassium carbonate; potassium iodide In acetonitrile at 20 - 82℃; for 24h; Reagent/catalyst; | |
| Stage #1: 3-(4-chlorobutyl)-5-cyanoindole With copper(l) iodide In diethyl ether for 3.5h; Inert atmosphere; Reflux; Stage #2: 5-(piperazin-1-yl)benzofuran-2-carboxylic acid ethyl ester With sodium methylate In diethyl ether at 90℃; for 5.5h; Concentration; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; | 8.9 g |
- 92886-57-2
1,1-dimethoxy-6-chlorohexane
- 163521-11-7
5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl)benzofuran-2-carboxylic acid ethyl ester
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: methanol; water / 1 h / 72 °C / Inert atmosphere 2.1: copper(l) iodide / diethyl ether / 3.5 h / Inert atmosphere; Reflux 2.2: 5.5 h / 90 °C / Inert atmosphere View Scheme |
- 56621-48-8
1-(4-hydroxyphenyl)piperazine
- 163521-11-7
5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl)benzofuran-2-carboxylic acid ethyl ester
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine; magnesium chloride / toluene / 7 h / Inert atmosphere; Reflux 2.1: sodium iodide; potassium carbonate / N,N-dimethyl-formamide / 5 h / Reflux 3.1: copper(l) iodide / diethyl ether / 3.5 h / Inert atmosphere; Reflux 3.2: 5.5 h / 90 °C / Inert atmosphere View Scheme |
- 163521-11-7
5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl)benzofuran-2-carboxylic acid ethyl ester
| Conditions | Yield |
|---|---|
| With potassium hydroxide In methanol | 80% |
- 163521-11-7
5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl)benzofuran-2-carboxylic acid ethyl ester
- 163521-12-8
vilazodone
| Conditions | Yield |
|---|---|
| With potassium hydroxide In methanol | 72% |
| Multi-step reaction with 2 steps 1: KOH / methanol / 3 h / Heating 2: 72 percent / 1-methyl-2-chloropyridinium iodide; Et2NiPr; NH3(g) / 1-methyl-pyrrolidin-2-one View Scheme | |
| With ammonium hydroxide In water; acetonitrile at 0 - 20℃; for 98h; Time; Reagent/catalyst; Temperature; |
Ethyl 5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl) benzofuran-2-carboxylate Specification
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