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Ethylene glycol monoethyl ether |
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Ethylene glycol monoethyl ether Chemical Properties
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IUPAC Name: 2-Ethoxyethanol
Empirical Formula: C4H10O2
Molecular Weight: 90.121
Canonical SMILES: CCOCCO
InChI: InChI=1S/C4H10O2/c1-2-6-4-3-5/h5H,2-4H2,1H3
InChIKey: ZNQVEEAIQZEUHB-UHFFFAOYSA-N
EINECS: 203-804-1
Product Categories: Industrial / Fine Chemicals; Ethylene Glycols & Monofunctional Ethylene Glycols; Monofunctional Ethylene Glycols
storage temp.: Flammables area
Water Solubility: miscible
FreezingPoint: -70 °C
Stability: Stable. Readily forms explosive mixtures with air - note the wide explosion range. Vapour may travel considerable distance to a source of ignition. Flammable. Incompatible with strong acids, strong bases, strong oxidizing agents, aluminium, alkalies
Index of Refraction: 1.399
Molar Refractivity: 23.86 cm3
Molar Volume: 98.4 cm3
Surface Tension: 28.6 dyne/cm
Density: 0.915 g/cm3
Flash Point: 44.4 °C
Enthalpy of Vaporization: 39.22 kJ/mol
Boiling Point: 135.6 °C at 760 mmHg
Vapour Pressure: 3.28 mmHg at 25 °C
Appearance: clear colorless liquid
Melting Point: -100 °C
Classification Code of Ethylene glycol monoethyl ether (CAS NO.96231-36-6): Mutation data; Reproductive Effect; Skin / Eye Irritant; TSCA Flag S [Substance is identified in a proposed or final SNUR (Significant New Use Rule) under TSCA]; Tumor data
Ethylene glycol monoethyl ether Uses
As with other glycol ethers, Ethylene glycol monoethyl ether (CAS NO.96231-36-6) has the useful property of being able to dissolve chemically diverse compounds. It will dissolve oils, resins, grease, waxes, nitrocellulose, and lacquers. This is an ideal property as a multi-purpose cleaner and therefore 2-ethoxyethanol is used in products such as varnish removers and degreasing solutions.
Ethylene glycol monoethyl ether Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LCLo | inhalation | 3000ppm/24H (3000ppm) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Public Health Reports. Vol. 45, Pg. 1459, 1930. |
| guinea pig | LD50 | oral | 1400mg/kg (1400mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941. |
| guinea pig | LD50 | unreported | 3070mg/kg (3070mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 47(5), Pg. 84, 1982. | |
| mouse | LC50 | inhalation | 1820ppm/7H (1820ppm) | BEHAVIORAL: ANALGESIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA KIDNEY, URETER, AND BLADDER: HEMATURIA | Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 157, 1943. |
| mouse | LD50 | intraperitoneal | 1707mg/kg (1707mg/kg) | LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA BLOOD: CHANGES IN SPLEEN KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947. |
| mouse | LD50 | intravenous | 3900mg/kg (3900mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 880, 1971. |
| mouse | LD50 | oral | 2451mg/kg (2451mg/kg) | Kodak Company Reports. Vol. MSDS-10, Pg. 170A, 1982. | |
| mouse | LD50 | unreported | 5799mg/kg (5799mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 47(5), Pg. 84, 1982. | |
| mouse | LDLo | subcutaneous | 5gm/kg (5000mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 42, Pg. 355, 1931. | |
| rabbit | LD50 | intravenous | 900mg/kg (900mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 880, 1971. |
| rabbit | LD50 | oral | 1275mg/kg (1275mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(10), Pg. 78, 1988. | |
| rabbit | LD50 | skin | 3300mg/kg (3300mg/kg) | Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 54, 1974. | |
| rabbit | LD50 | subcutaneous | 2gm/kg (2000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 880, 1971. | |
| rat | LC50 | inhalation | 2000ppm/7H (2000ppm) | Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 54, 1974. | |
| rat | LD50 | intraperitoneal | 2800mg/kg (2800mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 880, 1971. | |
| rat | LD50 | intravenous | 2400mg/kg (2400mg/kg) | Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 54, 1974. | |
| rat | LD50 | oral | 2125mg/kg (2125mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: WITHDRAWAL LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(3), Pg. 48, 1988. |
| rat | LD50 | skin | 3900mg/kg (3900mg/kg) | Toxicologist. Vol. 4, Pg. 180, 1984. | |
| rat | LD50 | subcutaneous | 3400mg/kg (3400mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 880, 1971. | |
| rat | LD50 | unreported | 7750mg/kg (7750mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 47(5), Pg. 84, 1982 |
Ethylene glycol monoethyl ether Safety Profile
Hazard Codes: 
T
Risk Statements: 60-61-10-20/21/22
R60:May impair fertility.
R61:May cause harm to the unborn child.
R10:Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 53-45
S53:Avoid exposure - obtain special instructions before use.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 1171 3/PG 3
WGK Germany: 1
RTECS: KK8050000
HazardClass: 3
PackingGroup: III
Ethylene glycol monoethyl ether Specification
Ethylene glycol monoethyl ether (CAS NO.96231-36-6), its Synonyms are 110-80-5 ; 2-Ethoxyethanol ; Ethanol, 2-ethoxy- ; Athylenglykol-monoathylather ; Ethyl cellosolve ; Ethyl ethylene glycol ; beta-Ethoxyethanol .