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Ethylurea
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Name

Ethylurea

 EINECS 210-898-8
CAS No. 625-52-5 Density 1.005 g/cm3
PSA 55.12000 LogP 0.76580
Solubility H2O: 0.1 g/mL, clear, colorless Melting Point 90-95 ºC
Formula C3H8 N2 O Boiling Point 136.3 ºC at 760 mmHg
Molecular Weight 88.1093 Flash Point 36.2 ºC
Transport Information N/A Appearance Beige to white solid
Safety 22-24/25 Risk Codes 68-37-20/21/22
Molecular Structure Molecular Structure of 625-52-5 (Ethylurea) Hazard Symbols HarmfulXn
Synonyms

Urea,ethyl- (6CI,7CI,8CI,9CI); 1-Ethylurea; Ethylurea; N-Ethylurea; NSC 53556

Article Data 35

Ethylurea Synthetic route

39076-43-2

S-methyl N-ethylthiocarbamate

A

625-52-5

N-Ethylurea

B

5188-07-8

sodium thiomethoxide

Conditions
ConditionsYield
With ammonia In water at 60℃; for 4h;A 98.5%
B 95%
39076-43-2

S-methyl N-ethylthiocarbamate

625-52-5

N-Ethylurea

Conditions
ConditionsYield
With ammonia In ethyl acetate93%
With ammonium hydroxide In 1,4-dioxane at 70℃; for 6h;
79-05-0

Propionamid

625-52-5

N-Ethylurea

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene; ammonia In methanol at 0 - 20℃; for 2h; Hofmann Rearrangement; Inert atmosphere;84%
542-85-8

Ethyl isothiocyanate

625-52-5

N-Ethylurea

Conditions
ConditionsYield
With diethyl ether; hydroxylamine
25684-38-2

N-ethyl-N'-hydroxy-thiourea

625-52-5

N-Ethylurea

Conditions
ConditionsYield
With water
With ethanol
64-17-5

ethanol

626-36-8

ethyl allophanate

75-04-7

ethylamine

625-52-5

N-Ethylurea

Conditions
ConditionsYield
at 150℃;
684-93-5

1-methyl-1-nitrosourea

75-04-7

ethylamine

625-52-5

N-Ethylurea

Conditions
ConditionsYield
With water
556-89-8

nitrourea

75-04-7

ethylamine

625-52-5

N-Ethylurea

626-36-8

ethyl allophanate

75-04-7

ethylamine

625-52-5

N-Ethylurea

Conditions
ConditionsYield
at 150℃;
With ethanol at 150℃;
at 150℃; oder in alkoh. Loesung;
39197-62-1

N-ethyl-N'-nitro-guanidine

75-04-7

ethylamine

625-52-5

N-Ethylurea

Conditions
ConditionsYield
With water

Ethylurea Chemical Properties

IUPAC Name: Ethylurea
Formula  : C3H8N2O
Molecular Weight: 88.11
Molecular Structure of Ethylurea (625-52-5):

Density: 1.005 g/cm3 
Flash Point: 36.2 °C
Melting Point:87-90 °C(lit.)
Boiling Point: 136.3 °C at 760 mmHg
Index of Refraction: 1.44
Molar Refractivity: 23.1 cm3 
Molar Volume: 87.6 cm3
Polarizability: 9.16× 10-24cm3 
Surface Tension: 35.2 dyne/cm
Appearance: white to beige crystals
Enthalpy of Vaporization: 37.37 kJ/mol 
Vapour Pressure: 7.44 mmHg at 25°C 
Water Solubility: 2.64e+004 (mg/L) at 25°C 
Product Categories: pharmaceutical intermediates;carbonyl compounds;organic building blocks;ureas.

Ethylurea Toxicity Data With Reference

1.    

mmo-clr 400 mmol/L

     FOMIAZ    Folia Microbiologica (Prague). (Academia, Vodickova 40, CS-112 29 Prague 1, 20 (1975),452.
2.    

orl-mus TDLo:2 g/kg (10D preg):REP

     TJADAB    Teratology, A Journal of Abnormal Development. 23 (1981),335.
3.    

orl-rat LD:>250 mg/kg

     NCNSA6    National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. 5 (1953),47.
4.    

par-mus LDLo:6610 mg/kg

     JPETAB    Journal of Pharmacology and Experimental Therapeutics. 52 (1934),216.

Ethylurea Consensus Reports

EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

Ethylurea Safety Profile

Mildly toxic by parenteral route. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Safety Information about Ethylurea (625-52-5):
Hazard Codes:
Xn:
Risk Statements about Ethylurea (625-52-5):
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed. 
R37: Irritating to the respiratory system.
R68:   Possible risk of irreversible effects.
Safety Statements about Ethylurea (625-52-5):
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
RIDADR: 1325
WGK Germany: 3
PackingGroup: III

Ethylurea Specification

  The chemical synonyms of Ethylurea (625-52-5) are Ethylurea ; Ethylurea (mono) ; Ethanolurea ; Ethylcarbamide ; N-ethylurea ; 1-Ethyl-ure ; 1-Ethylurea ; Ethvlurea .It can be used as intermediate synthesis for medicine and pesticide. 
  Some important infamation about  the operation  and store of the product .If  contact with skin or eyes, flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.Get medical aid. Wash mouth out with water.Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.  Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Use only in a chemical fume hood.Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. 
 

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