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Fludiazepam
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Name

Fludiazepam

 EINECS N/A
CAS No. 3900-31-0 Density 1.32 g/cm3
PSA 32.67000 LogP 2.79350
Solubility N/A Melting Point 88 - 92oC
Formula C16H12 Cl F N2 O Boiling Point 498.1 °C at 760 mmHg
Molecular Weight 302.735 Flash Point 255.1 °C
Transport Information N/A Appearance N/A
Safety Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. Used as a tranquilizer. Note: This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.14 (1985). When heated to decomposition it emits toxic fumes of F−, Cl−, and NOx. See also DIAZEPAM. Risk Codes N/A
Molecular Structure Molecular Structure of 3900-31-0 (Fludiazepam) Hazard Symbols N/A
Synonyms

2H-1,4-Benzodiazepin-2-one,7-chloro-5-(o-fluorophenyl)-1,3-dihydro-1-methyl- (7CI,8CI);7-Chloro-5-(2-fluorophenyl)-1-methyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one;Erispan;Fludiazepam;ID 540;Ro 5-3438;

Article Data 9

Fludiazepam Chemical Properties

Chemical Name: Fludiazepam
IUPAC NAME: 7-Chloro-5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
CAS No.: 3900-31-0
Molecular Formula: C16H12ClFN2O
Molecular Weight: 302.73 g/mol
Density: 1.32 g/cm3 
Flash Point: 255.1 °C
Boiling Point: 498.1 °C at 760 mmHg
 Fludiazepam (3900-31-0) (marketed under the brand name Erispan) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.Following is the structure:


The chemical synonymous of Fludiazepam (3900-31-0) are Fludiazepam ; 7-Chloro-(2-fluorophenyl)-1,3-dihydro-1-menthyl-2h-1,4-benzodiazepin-2-one ; 1,3-Dihydro-7-chloro-5-(o-fluorophenyl)-1-methyl-2h-4-benzodiazepin-2-one ; 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-1-methyl-2h-4-benzodiazepin-2-one ; 7-Chloro-5-(2-fluorophenyl)-1-methyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one ; 7-Chloro-5-(2-fluorophenyl)-1-methyl-1h-1,4-benzodiazepin-2(3h)-one ; 7-Chloro-5-(o-fluorophenyl)-1,3-dihydro-1-methyl-2h-1,4-benzodiazepin-2-one ; 7-Chloro-5-(o-fluorophenyl)-1,3-dihydro-1-methyl-2h-4-benzodiazepin-2-one

Fludiazepam Toxicity Data With Reference

1.    

orl-rat LD50:1740 mg/kg

     YAKUD5    Gekkan Yakuji. Pharmaceuticals Monthly. 22 (1980),811.
2.    

ipr-rat LD50:315 mg/kg

     IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.
3.    

scu-rat LD50:7600 mg/kg

     IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.
4.    

orl-mus LD50:830 mg/kg

     IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.
5.    

ipr-mus LD50:360 mg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),698.
6.    

scu-mus LD50:1150 mg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),698.

Fludiazepam Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. Used as a tranquilizer. Note: This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.14 (1985). When heated to decomposition it emits toxic fumes of F−, Cl−, and NOx. See also DIAZEPAM.