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| Name |
Flumethiazide |
EINECS | N/A |
| CAS No. | 148-56-1 | Density | 1.99g/cm3 |
| PSA | 135.45000 | LogP | 2.93080 |
| Solubility | 1.05g/L(room temperature) | Melting Point |
306.6°C |
| Formula | C8H6 F3 N3 O4 S2 | Boiling Point | 560°Cat760mmHg |
| Molecular Weight | 329.281 | Flash Point | 292.5°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Moderately toxic by intraperitoneal and intravenous routes. When heated to decomposition it emits very toxic fumes of SOx, NOx, and F−. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
6-(Trifluoromethyl)-1,4,2-benzothiadiazine-7-sulfonamido1,1-dioxide; 6-Trifluoromethyl-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 6-Trifluoromethyl-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide;7-Sulfamoyl-6-trifluoromethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; Ademil;Ademol; Fludemil; Flumethiazid; Flumethiazide; Flumetiazid; NSC 44626; Routrax;Trifluoromethylthiazide |
Flumethiazide Chemical Properties
EINECS of Flumethiazide (CAS NO.148-56-1): 205-717-4
Empirical Formula: C8H6F3N3O4S2
Molecular Weight: 329.2761 g/mol
Index of Refraction: 1.673
Density: 1.99 g/cm3
Flash Point: 292.5 °C
Enthalpy of Vaporization: 84.25 kJ/mol
Boiling Point: 560 °C at 760 mmHg Vapour
Pressure: 1.42E-12 mmHg at 25 °C
Structure of Flumethiazide (CAS NO.148-56-1):
.png)
IUPAC Name: 1,1-Dioxo-6-(trifluoromethyl)-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
Canonical SMILES: C1=C(C(=CC2=C1NC=NS2(=O)=O)S(=O)(=O)N)C(F)(F)F
InChI: InChI=1S/C8H6F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-3H,(H,13,14)(H2,12,15,16)
InChIKey: RGUQWGXAYZNLMI-UHFFFAOYSA-N
Flumethiazide Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 1760mg/kg (1760mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 273, 1961. |
| mouse | LD50 | intravenous | 910mg/kg (910mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: ATAXIA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Journal of Pharmacology and Experimental Therapeutics. Vol. 128, Pg. 405, 1960. |
| mouse | LD50 | oral | > 8gm/kg (8000mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 273, 1961. |
Flumethiazide Safety Profile
Moderately toxic by intraperitoneal and intravenous routes. When heated to decomposition Flumethiazide (CAS NO.148-56-1) emits very toxic fumes of SOx, NOx, and F−.
Flumethiazide Specification
Flumethiazide , its cas register number is 148-56-1. It also can be called Ademol ; 6-(Trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide ; 6-(Trifluoromethyl)-1,2,4-benzo-thiadiazine-7-sulfonamide 1,1-dioxide ; and 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide (8CI)(9CI) .
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