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| Name |
Flunitrazepam |
EINECS | 216-597-8 |
| CAS No. | 1622-62-4 | Density | 1.39g/cm3 |
| PSA | 78.49000 | LogP | 2.57150 |
| Solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1 mg/mL | Melting Point |
166-167 °C |
| Formula | C16H12FN3O3 | Boiling Point | 540.9°Cat760mmHg |
| Molecular Weight | 313.288 | Flash Point | 280.9°C |
| Transport Information | N/A | Appearance | UN 1230 3/PG 2 |
| Safety | Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Human reproductive effects by ingestion and intramuscular routes: Apgar score of newborn and other neonatal and postnatal effects. Experimental reproductive effects. Mutation data reported. Human systemic effects by ingestion: coma. Used as a hypnotic agent. Note: This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.14 (1985). When heated to decomposition it emits toxic fumes of F− and NOx. | Risk Codes | 22-36-39/23/24/25-23/24/25-11 |
| Molecular Structure |
|
Hazard Symbols |
 Xn T F
|
| Synonyms |
2H-1,4-Benzodiazepin-2-one,5-(o-fluorophenyl)-1,3-dihydro-1-methyl-7-nitro- (7CI,8CI);5-(2-Fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one;5-(2-Fluorophenyl)-1-methyl-7-nitro-1,3-dihydrobenzo[e][1,4]diazepin-2-one;5-(o-Fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one;7-Nitro-1-methyl-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2(1H)-one;Flunidazepam;Flunipam;Flunitrazepam;Fluridrazepam;Narcozep;Ro 5-4200;Rohypnol;Roipnol;Silece; |
Flunitrazepam Chemical Properties
Molecular Structure of Flunitrazepam (CAS NO.1622-62-4):
.gif)
IUPAC Name: 5-(2-Fluorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one
Empirical Formula: C16H12FN3O3
Molecular Weight: 313.2832
EINECS: 216-597-8
Storage temp.: 2-8°C
Solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1 mg/mL
Index of Refraction: 1.648
Molar Refractivity: 81.84 cm3
Molar Volume: 224.8 cm3
Surface Tension: 52.5 dyne/cm
Density: 1.39 g/cm3
Flash Point: 280.9 °C
Enthalpy of Vaporization: 81.87 kJ/mol
Boiling Point: 540.9 °C at 760 mmHg
Vapour Pressure: 9.13E-12 mmHg at 25 °C
Melting Point: 166-167 °C
Water Solubility: 72.8 mg/L at 25 °C
Classification Code: Anti-Anxiety Agents; Central Nervous System Agents; Central Nervous System Depressants; Drug / Therapeutic Agent; GABA Agents; GABA modulators; Human Data; Mutation data; Neurotransmitter Agents; Psychotropic Drugs; Reproductive Effect; Sedative-hypnotic; Tranquilizing Agents
Flunitrazepam Uses
Just as with other hypnotics, Flunitrazepam should only be used on a short-term basis or in those with chronic insomnia on an occasional basis.
Flunitrazepam Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | oral | 3478ug/kg (3.478mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: COMA VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Critical Care Medicine. Vol. 17, Pg. 1355, 1989. |
| human | LDLo | oral | 430ug/kg (0.43mg/kg) | Journal of Analytical Toxicology. Vol. 11, Pg. 278, 1987. | |
| human | TDLo | oral | 184ug/kg (0.184mg/kg) | BEHAVIORAL: COMA | Journal of Analytical Toxicology. Vol. 11, Pg. 278, 1987. |
| infant | TDLo | oral | 222ug/kg (0.222mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE BEHAVIORAL: GENERAL ANESTHETIC LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 2597, 1996. |
| mouse | LD50 | intramuscular | > 2gm/kg (2000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1277, 1985. |
| mouse | LD50 | intraperitoneal | 1050mg/kg (1050mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1277, 1985. |
| mouse | LD50 | oral | 1200mg/kg (1200mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1277, 1985. |
| mouse | LD50 | subcutaneous | > 4gm/kg (4000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1277, 1985. | |
| rat | LD50 | intramuscular | > 2gm/kg (2000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1277, 1985. |
| rat | LD50 | intraperitoneal | 1060mg/kg (1060mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1277, 1985. |
| rat | LD50 | oral | 415mg/kg (415mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1277, 1985. |
| rat | LD50 | subcutaneous | > 4gm/kg (4000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1277, 1985. |
| women | TDLo | oral | 127ug/kg (0.127mg/kg) | BEHAVIORAL: COMA | Archives of Internal Medicine. Vol. 145, Pg. 663, 1985. |
Flunitrazepam Safety Profile
Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Human reproductive effects by ingestion and intramuscular routes: Apgar score of newborn and other neonatal and postnatal effects. Experimental reproductive effects. Mutation data reported. Human systemic effects by ingestion: coma. Used as a hypnotic agent. Note: This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.14 (1985). When heated to decomposition it emits toxic fumes of F− and NOx.
Safety Information of Flunitrazepam (CAS NO.1622-62-4):
Hazard Codes: 
Xn,
T,
F
Risk Statements: 22-36-39/23/24/25-23/24/25-11
R22:Harmful if swallowed.
R36:Irritating to eyes.
R39:Danger of very serious irreversible effects.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R11:Highly flammable.
Safety Statements: 7-16-36/37-45-36-26
S7:Keep container tightly closed.
S16:Keep away from sources of ignition.
S36/37:Wear suitable protective clothing and gloves.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 1230 3/PG 2
WGK Germany: 2
RTECS: DF2385000
HazardClass: 6.1(b)
PackingGroup: III
Flunitrazepam Specification
Flunitrazepam (CAS NO.1622-62-4), its Synonyms are 1,3-Dihydro-5-(o-fluorophenyl)-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one ; 1-Methyl-7-nitro-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2(1H)-one ; 5-(o-Fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one ; Flunitrazepamum ; Narcozep ; Primun ; Ro 5-4200 ; Rohypnol ; 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-5-(2-fluorophenyl)-1-methyl-7-nitro- ; 2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-1-methyl-7-nitro- .