Basic Information | Post buying leads | Suppliers | Cas Database |
Name |
Flurandrenolide |
EINECS | 216-196-8 |
CAS No. | 1524-88-5 | Density | 1.314 g/cm3 |
PSA | 93.06000 | LogP | 2.49870 |
Solubility | 295mg/L(25 oC) | Melting Point |
247-255° |
Formula | C24H33FO6 | Boiling Point | 578.75 °C at 760 mmHg |
Molecular Weight | 436.521 | Flash Point | 303.817 °C |
Transport Information | N/A | Appearance | N/A |
Safety | Risk Codes | N/A | |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
Pregn-4-ene-3,20-dione,6a-fluoro-11b,16a,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone(7CI,8CI);33379;6a-Fluoro-11b,21-dihydroxy-16a,17a-(isopropylidenedioxy)pregn-4-ene-3,20-dione;6a-Fluoro-16a-hydroxyhydrocortisone 16,17-acetonide;Alondra F;Cordran;Drenison;Drocort;Fluadrenolone;Fludroxycortide;Fluorandrenolone;Fluorandrenolone acetonide;Fluoroandrenolone acetonide;Flurandrenolide;Flurandrenolone;Flurandrenolone acetonide;Haelan;HaldroneF;L 33379;Sermaka; |
Article Data | 12 |
flunisolide
flurandrenolide
Conditions | Yield |
---|---|
With Wilkinson's catalyst; hydrogen In ethanol; toluene for 65h; Ambient temperature; | 76% |
(tris(triphenylphosphine)rhodium) chloride In ethanol; chloroform; toluene | |
(tris(triphenylphosphine)rhodium) chloride In ethanol; chloroform; toluene |
Conditions | Yield |
---|---|
With hydrogenchloride at -15 - -10℃; for 2h; | A 39% B 27% |
flurandrenolide
barium(II) acetate
21-(acetyloxy)-6α-fluoro-11β-hydroxy-16α,17-<(1-methylethylidene)bis(oxy)>pregna-1,4-diene-3,20-dione
Conditions | Yield |
---|---|
1.) Corynebacterium simplex, DMF, 20 h, 2.) glacial acetic acid, acetic anhydride, room temp., 24 h; Yield given. Multistep reaction; |
flurandrenolide
6α-Fluoro-16α,17α-isopropylidenedioxandrost-4-en-11β-ol-3-one-17β-carboxylic acid
Conditions | Yield |
---|---|
With potassium hydroxide; oxygen In methanol; dichloromethane for 6h; Ambient temperature; Yield given; |
flurandrenolide
n-hexadecanoyl chloride
6α-Fluoro-11β-hydroxy-16α,17α-[(1-methylethylidene)bis(oxy)]-21-palmitoyloxypregn-4-ene-3 20-dione
Conditions | Yield |
---|---|
In 1,4-dioxane; pyridine; ethanol; n-heptane; chloroform |
The Flurandrenolide, with the CAS registry number 1524-88-5, is also known as 6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregn-4-ene-3,20-dione, cyclic 16,17-acetal with acetone. This chemical's molecular formula is C24H33FO6 and formula weight is 436.52. What's more, its systematic name is called (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS,12S)-12-Fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol -2-one.
Physical properties about this chemical are: (1)ACD/LogP: 2.05; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.05; (4)ACD/LogD (pH 7.4): 2.05; (5)ACD/BCF (pH 5.5): 21.17; (6)ACD/BCF (pH 7.4): 21.17; (7)ACD/KOC (pH 5.5): 309.43; (8)ACD/KOC (pH 7.4): 309.43; (9)#H bond acceptors: 6; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 71.06 Å2; (13)Index of Refraction: 1.572; (14)Molar Refractivity: 109.44 cm3; (15)Molar Volume: 332.3 cm3; (16)Surface Tension: 52.6 dyne/cm; (17)Density: 1.31 g/cm3; (18)Flash Point: 303.8 °C; (19)Enthalpy of Vaporization: 99.45 kJ/mol; (20)Boiling Point: 578.7 °C at 760 mmHg; (21)Vapour Pressure: 8.35E-16 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C1\C=C5/[C@](C)(CC1)[C@@H]2[C@H]([C@H]3[C@](C[C@@H]2O)([C@@]4(OC(O[C@@H]4C3)(C)C)C(=O)CO)C)C[C@@H]5F
(2)InChI: InChI=1/C24H33FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h7,13-14,16-17,19-20,26,28H,5-6,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1
(3)InChIKey: POPFMWWJOGLOIF-XWCQMRHXBO