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6466
Table 1. BoNT/A LC inhibitory activitya
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b
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IC50 (lM)
2
0.9 0.1
3a
3b
4a
4b
4c
4d
5a
5b
5c
5d
5e
5f
21
71
5
1
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41 0.3
45
n.a.
38
7
7
4.4 0.1
0.7 0.1
9
2
5.1 0.6
25
6
0.8 0.1
0.6 0.1
5g
5h
5i
13
2
5
0.6
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5j
5k
17 0.4
12
3
a Inhibitors were evaluated as previously described.17
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yielding three new small molecule inhibitors with com-
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LC flexibility are warranted.
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Acknowledgments
This work was supported by contract NO1-AI30050
from the National Institutes of Health and The Skaggs
Institute for Chemical Biology. We wish to thank Dr.
Lisa Eubanks for helpful discussions.
Supplementary data
Supplementary data associated with this article can be
16. (a) Ho, C. Y.; Strobel, E.; Ralbovsky, J.; Galemmo, R. A.,
Jr. J. Org. Chem. 2005, 70, 4873; (b) Marson, C. M.; Savy,
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References and notes
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