840
ISHMIYAROV et al.
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amines and hemiacetals (general procedure). To 0.5 g
(4 mmol) of ethyl acetoacetate 15 mmol of a primary
amine and 68 mmol of formaldehyde in the form of
hemiacetals was added at stirring and the mixture was
heated for 5 h at 65°С. MeOH was distilled off at a
reduced pressure, and 20 mL of CH2Cl2 was added.
The reaction mixture was washed with water (3 × 10 mL),
dried with anhydrous Na2SO4, the solvent removed at a
reduced pressure. The residue was chromatographed
on a column packed with silica gel (eluent chloroform
with increasing content of MeOH from 0 to 10% or
petroleum ether with increasing content of EtOAc
from 0 to 2%). The yields of the products Iа, Ib, IIа,
IIb, IIIа, IIIb, and IV are given in Table 2 and in the text.
ACKNOWLEDGMENTS
This research was financially supported by the
Russian Scientific Foundation (project no. 14-33-00022).
19. Fakhriev, A.M., Fakhriev, R.A., and Yarmukhamedov, R.G.,
RF Patent 2482163, 2012.
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Latypova, D.R., Spirikhin, L.V., and Dokichev, V.A.,
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