Rhodium-Catalyzed Asymmetric Hydroformylation of 1,1-Disubstituted Allylphthalimides
added to a 2-mL vial. After stirring for 10 min, the substrate
(0.05 mmol) and additional solvent were added to bring the
total volume of the reaction mixture to 1.0 mL. The vial was
transferred into an autoclave and taken out of the glovebox.
Carbon monoxide (10 bar) and hydrogen (10 bar) were
added sequentially. After the reaction the vial was cooled
and the pressure was carefully released in a well-ventilated
fume hood. The conversion and 2/3 ratio were determined
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1
by H NMR spectroscopy from the crude reaction mixture.
The enantiomeric excess was determined either by reducing
the aldehyde to the corresponding alcohol with
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Acknowledgements
This research was supported by the National Science Founda-
tion (NSF CHE 0956784), and China Scholarship Council.
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