Organic Process Research and Development p. 835 - 843 (2017)
Update date:2022-08-03
Topics:
Billamboz, Muriel
Imbs, Claire
Banaszak-Léonard, Estelle
Len, Christophe
We report herein a green and scalable one-pot, three-step, pinacol-coupling-rearrangement-reduction cascade reaction useful for the formation of 2,2-diphenylethanol derivatives. The reaction is carried out in water in the presence of a commercially available and regenerable supported acid under moderate pressure. A dozen of aromatic aldehydes have been successfully submitted to the standard protocol giving the target 2,2-diarylethanol derivatives in good yield (70-85%).
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