Journal of Organic Chemistry p. 1175 - 1179 (1986)
Update date:2022-09-26
Topics:
Walker, T. E.
Matheny, C.
Storm, C. B.
Hayden, H.
L-Tyrosine specifically labeled with 2H, 13C, 18O, or 15N has been synthesized by using a combination of organic synthetic methods and the β-tyrosinase enzyme activity of the bacterium Erwinia herbicola.The following L-tyrosine isotopomers were prepared: L-<4'-13C>tyrosine from <1-13C>phenol and L-serine, L-<3',5'-13C2>tyrosine from <2,2-13C2>phenol and L-serine, L-<4'-18O>tyrosine from <18O>phenol and L-serine, L-<15N>tyrosine from <15N>ammonium sulfate, phenol, and pyruvate, and L-<2',3',5',6'-2H4>tyrosine from
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