Bioorganic and Medicinal Chemistry Letters p. 1291 - 1295 (2007)
Update date:2022-07-30
Topics:
Lee, Sunkyung
Kim, Taemi
Lee, Byung Ho
Yoo, Sung-eun
Lee, Kyunghee
Yi, Kyu Yang
The C-3 substituents effect on NHE-1 inhibitory activity of (5-arylfuran-2-ylcarbonyl)guanidines, previously identified as potent NHE-1 inhibitors, was investigated. The introduction of amine or alkyl groups at the 3-position of the furan ring, next to the acylguanidine moiety, remarkably improves NHE-1 inhibitory potency. Especially the important finding is that 5-(2,5-dichloro)phenyl and 5-(2-methoxy-5-chloro)phenyl derivatives exhibit high NHE-1 inhibitory activities (IC50 < 0.02 μM) that match those of 3-unsubstituted derivatives.
View Morewebsite:http://www.hybio.com.cn
Contact:+86 755 26588093
Address:No.9 Linkong West Street, Hengdian Street, Huangpi District, Wuhan City, China.
Chengdu Gelipu Biotechnology Co., Ltd.
website:http://www.glp-china.com
Contact:86-28-82610909
Address:chegndu
Contact:86-512-69362780,69362785
Address:No.69 Weixin Road,Weiting Town,Suzhou Industrial Park
Contact:+86-15995924277
Address:WuZhongOu suzhou new south road 89
Shanghai Forever Biotech Co., Ltd.
Contact:+86-21-69734790
Address:Room 5017/5019、5022、5024 of Technology Innovation Centre, No.1155, Gongyuan East Rd, QingPu District, Shanghai China.
Doi:10.1016/j.tetlet.2007.12.005
(2008)Doi:10.1016/S0020-1693(00)88034-2
(1984)Doi:10.1007/BF01142797
(1985)Doi:10.1021/jm7013937
(2008)Doi:10.1039/c4dt00610k
(2014)Doi:10.1016/S0040-4039(01)84369-0
(1972)