Modular Phosphine-Aminophosphine Ligands
COMMUNICATIONS
a-benzoyloxyethenephosphonate 4a (64 mg, 0.25 mmol, S/C
100:1) in 1 mL of degassed CH2Cl2 was added. The resulting
mixture was transferred to an autoclave, which was then
charged with H2 (10 atm). The hydrogenation was per-
formed at room temperature for 24 h. After carefully releas-
ing the hydrogen gas, the reaction mixture was concentrated
under reduced pressure. The residue was purified through a
plug of silica gel (eluting with a mixture of hexanes/EtOAc,
2/1) to afford 5a. The enantiomeric excess was determined
by chiral GC.
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We are grateful for financial support from the National Natu-
ral Science Foundation of China (20873145, 20802076) and
the Knowledge Innovation Program of the Chinese Academy
of Sciences (DICP-S200802).
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